Beta blocker/Bisoprolol withdrawal and breathlessness

Hi, I already take magnesium.  The hyperthyroidism has a lot of the same symptoms, so everything is tied in together.  The BB might have been masking me being hyperthyroid for awhile - maybe a few months as I got really sick in August with some parasite that came in on lettuce.  That's when I noticed the real problems with the heartbeat.  It is sporadic now and I'm improving (almost a month now).  Some of the people on this site says it may take up to 6 months to feel normal again and I think I might be one of them because I am so severely sensitive to everything.  I even take 1/2 tablets of any new supplement just to see what it does before I'll start taking it regularly. 

I had problem with the heart beat too. At its worst I thought I was going nuts. I took double dose of Magnesium and then another doctor told me to take ubiquinol CoQ10 and L -Carnitine. I still get an occasional heart beat . But no where lose to what it was before. 

Hi Bob

You were very helpful once before to me and i would like to ask your advice and understanding of these drugs again.

20 days after stopping BB (Bis) i started getting palps. A while later started to feel dizzy off and on. Anyway went to see a cardiolodist and we did an stress MRI and 48 monitor of heart beat. He was happy that they are ventricular ectopics but said it might be better on BB so started me on Nebivolol 2.5mg. Because of the problems i had on BB before i only ever took half that dose. By the end of two weeks i was ill. My body didnt feel like my own. So he said stop them so i have. From when i started them again to now (stopped 21 days ago) i am dizzy everyday and that makes me feel sick. Ive seen a ENT and didnt think there was much wrong. Can really bad dizziness and fuzzy head everyday (some worse than others) be due to withdrawal of BB? The palps arnt so bad but wonder if thats because ive still got some BB in my body?

Thank you Bob. Your advice on here is so very helpful. Anyone else dizzy coing off BB and if so how long for?

Hi Danny.  Not Bob, but a person coming off these BB's after 6 years.  I have had palps, shortness of breath and the dizziness and unsteadiness on my feet on and off (got off them about 3 1/2 weeks ago).  A lovely person on this thread suggested I take more magnesium.  I was taking a calcium magnesium supplement but I added more magnesium.  It has really helped a lot.  It calms down the heart because magnesium affects muscle and of course, the heart is a big muscle.  Do some research for yourself and make a decision.  I found it was extremely helpful.  This takes a while to get off these thigns....

Hi, Danny

I stopped BBs 2 times (Bisoprolol and then Nebivolol).

When I have quit Bisoprolol, I felt good for around 20-25 days, without any symptoms. And then, after 25 days, my HR jumped to 100-120 while resting all the time.

My explanation is that my body was so filled with Bisoprolol (I was taking it for 1 year) and that it was stored in all vessels and cells and that it needed 20-25 days until those old amounts disappeared.

Then it hit me for real.

So, in my case, these are problems which I have been experiencing:

1. HR while resting around 100 all day long for 2-3 weeks. Then it started to get lower, like 90-ish for 1-2 weeks, then 85 etc

2. 3-4 weeks after a jump in a HR, I started to have anxiety and I was too sensitive to sunlight, light in general, loud noises. It got better eventually, week by week

3. 1 Month after a start of a too high HR, I started to have unexplained bouts of dizziness, after walking or doing any activity. On some days, I needed to lay for 1 hour after any activity, because of insane dizziness. Also, when I was dizzy, I had problems with breathing (I don't know was it anxiety due to dizziness or some problems with breathing related to a central nervous system)

4. other problems like nausea, headaches, pain in abdomen and lungs during a withdrawal, those lasted 2-3-4 weeks

The same as you, I had some withdrawal problems (during the 1st attempt) and docs have put me back on BBs (this time Nebivolol). I also didn't want to take the full dose but only 1/2 or 1/3rd, but I still felt bad on it (dizziness all the time on Nebivolol, and breathing problems, as if my brain fails to send signals to my lungs to take a breath. I had less side effects than on Bisoprolol, but I still felt horrible).

Anyway, after a few Months, I decided to wean off again, but slowlier this time (it lasted 6 Months this time) and it was easier.

I have experienced the same symptoms as while quitting Bisoprolol, so I was less scared this time, since I have been through this before and all withdrawal symptoms repeated more or less in the same order as 1st time.

So, about dizziness: I didn't have it while taking Bisoprolol, but I did have it on Nebivolol.

But, I did have it both when quitting Bisoprolol and Nebivolol, as a withdrawal symptom.

My advice about dizziness: try to walk even during a withdrawal, do some light stretching and excercise at home to get your blood flowing through your brain and your body. Drink a lot of fluids. If you feel dizzy, try to shower a few times per day. Also, when you have an attack of dizziness, try to eat some sugar or something.

All I can say: I have been there twice and it goes away eventually.

Imo, my biggest problem and a problem which lasted the longest is anxiety and chemicals in your brain which are totally out of balance after a few years of taking BBs which affect heart, but also our central nervous system.

So, I needed 2 Months for my HR to settle down, but a few months for my Central nervous system to settle down.

Also about dizziness, mine was gone after a few weeks. It starts randomly after 5-8 weeks of a withdrawal (not in the beginning, probably because you still have a lot of drug in your brain inside of a blood-brain barrier, and it takes some time to leave your brain-system), but it gets better each new week slowly. Just don't be scared, if possible.

And ask whatever you need, good luck

Hi Bob

Thank you for your reply.It is so helpful to hear other peoples stories as you don’t feel alone and that no one understands.

Much of what you write is like a mirror image of my issues on BB. 20 days after stopping BB for the first time (took them that time for about 6 months in total) I started getting palpations. After about another 3 to 5 weeks the odd dizzy spell as well.Some days no dizziness though. I went to see a cardiologist who carried out a stress MRI and 48 tape of my heart beat but was happy overall but said try this BB (nebivolol) as it works better that Bisoprolol. So I did.

Two weeks after trying it I was in a terrible state. Always dizzy feeling sick and wobbly at times and like I was a zombie…all this on less than half a 2,5mg tablet!. So after taking to him he said stop it. So I did. That was 22 days ago and since then I’ve been dizzy most days and often can feel a bit wobbly although my legs and arms never actually wobble.

Did you ever feel wobbly in your legs and arms Bob?

Also the HR shoots up. But I knew that would happen from the first time I stopped BB. Walking along the high street today I looked at my fitbit and it showed 131bpm. I was only walking at a normal speed.

Bob, headache? Yes… I have what is like a mild migraine headache that just seems to come and go all the time in the last few weeks. Was that like you? Also like you pain in the abdomen and chest tightness and the feeling that it is too much effort at times to try and talk to people and the tightness makes me cough.

And like you it was if my lungs had forgotten to tell my lungs to breath…that seems to have gone now but I thought I was going mad thinking that.

Why do you say take a shower a few times a day if dizzy?

Its the dizziness that the main problem for me now along with the weak legs feeling. Its like a fog in my brain at times and I feel unbalanced yet went to a ENT specialist who said I have excellent balance so it must be in the brain I am guessing.

One last thing Bob, I do feel scared and feel like giving up at times so your posts help me feel positive. Thanks.

Hi, Danny

I didn't feel wobbly.

About other things:

1. pain in abdomen and lungs when you quit BBs: when you take Bbs, they slow down your heart and organs, and some tests have shown that your muscles do atrophy to some extent due to less blood and food getting to them when you take BBs. So, when you take BBs, your body will be in a weaker shape.

Add to this that if you can't walk too much while on BBs due to side effects like problems with breathing, feeling ill or dizzy, then you will walk even less than you should and your body will atrophy even more.

Now, imagine that your muscles were at 100% before BBs with a normal amount of blood and food reaching to them.

When you take BBs, you will get only 80% of blood and food, and your muscles will get weaker.

Now, when you again quit BBs, your heart will start to pump faster and you will again receive more blood and food to your organs. This is why your muscles and lungs hurt now, because they are now forced to work at 100% instead of 80%, and more or less, they are growing back to normal levels as if you are going to gym or playing sports every day (even though you aren't doing anything).

2. about dizziness, while on Nebivolol, well it is a side effect. I had dizziness all day long.

About dizziness when you quit BBs, well BBs were making our blood vessels wider to lower blood pressure.

And then, our body is adjusted to these wide vessels.

When you quit BBs, blood vessels aren't that wide anymore, and it takes some time until our bodies readjust.

Again, imagine if your blood vessels were at 100% before BBs. Then during BBs, they were at 120% (very wide). And now, when you quit them, they go back to 100%. But for some time, it is a shock for your body since suddenly less blood can get to certain organs (brain, in this case) due to this 120% to 100% change in vessels.

Anyway, both pain in abdomen, lungs and dizziness will go away eventually.

About taking a shower, I felt better better when I showered or put some cold water on my face, drink some juice right away. It helped during the worst days on withdrawal's dizziness.

For the end, slowlier weaning off always help.

But if you can't do anything about it anymore, magnesium, lots of water, vitamins help (my doc told me to always drink lots of water, not only during a withdrawal, because when you have more fluids in your body, you have a higher blood volumen and heart will pump slower). Also, low doses of Valium can help during the worst period (Valium will slow down your too high HR until it returns to normal, plus it will help with anxiety). I don't know how is it with your docs and Valium, my docs told me: feel free to take Valium during a withdrawal...

Hi,

My RAMIPRIL and BISOPROLOL were both increased to 5mg per day about 10 days ago by my Cardiologist.  Ever since he increased the dose I have felt TERRIBLE. I spend all night TRYING to catch my breatch..literally suffocating.....NO MORE,,I am NOT taking todays dose or any other days..NO MORE. I have had enaf. Can I stop "Cold turkey" or must I wean myself off this crap....God also i feel 100 years old...everywhere..muscles...bones, joints..everywheree hurts..cant walk..cant move...This stuff is HORRIBLE.....Liam B

Hi

You have to wean off surely from Bisoprolol.

How long have you been taking it (weeks, months, years)?

If you quit cold turkey, you can suffer a stroke or heart attack (rebound high blood pressure, dangerous arrhytmias), since it is a very dangerous drug to quit.

Hi Liam, I'm sorry to hear about your battles with the medications.  I went off all medications 14 years ago, and am still alive.  But you need to wean yourself off them - cold turkey is dangerous.  I suggest you investigate the root cause of your metabolic diseases, which is hyperinsulinemia, for which the treatment is a very low carb, high fat diet.  There is plenty of information on this topic on the internet.  I switched to this style of eating several years ago, and I am sure it is the reason why I am still alive.

Hi Bob, I'm trying to get information regarding stopping Bisoprolol.  My mum was on the medication for 3 months and after a three month review her medication was increased from 1.25 to 3.75, we expressed concern about this and the monitoring of it as he gave us another appointment for 3 months. My concern was that how would we know if her heart rate was slowed to a dangerous level to which he was very dismisive. When admitted to hospital she had 1 dose of 3.75 and her HR dropped dangerously low and they stopped the medication immediately but did not replace it with anything else or put her back on the 1.25. Two days later she arrested, thankfully they brought her back but did experience much distress which they could not explain and passed away. As you can imagine I am totally devastated and I am in discusisons with them as I feel the withdrawal of the medication was to blame and they are denying this.  From what everyone is saying in this discussion, it is not as unrealistic as they are making out. Would welcome your viewpoint and any other relevant information you may have.  I am not writing this to cause any alarm in anyway

Hi, I am very sorry for your loss.

About a withdrawal, I had insane problems with stopping 1,25 of Bisoprolol and 1,25 of Nebivolol and I needed months of weaning off to survive.

I know what happened to me and how bad I felt. I think that I talked with 7 doctors about quitting BBs, 5 of them told me: it shouldn't be a problem, you should be fine after 1-2 weeks. You will experience minor problems.

Only two of them told me: if you are feeling that bad when you have quit them, take Valium or Xanax for a 1-2 Months in order to calm down your central nervous system and to slow down your heart rate.

I don't want to fight with docs, because we will again need their help in one way or another.

But from my experience, they have their opinion and that's it. They have learned in books that quitting BBs is a piece of cake (if you wean off for 2-4 weeks), and probably they had 100s of patients who have quit those drugs without any problems.

I don't know if we are crazy, different, too sensitive to this drug or what, but majority of people on these forums had a really tough time to quit BBs.

I ended at ER 2 times during a withdrawal. I knew that it was a withdrawal. Docs would tell me: no, that is some disease, you need to take drugs again.

Also, I tried to tell to some docs: I have read some forums and people on forums have more or less the same symptoms when they tried to quit the drug (as me).

Docs would usually say: don't read forums, people there are crazy and they think that they have every single disease and symptom in the world. Don't read forums with diseases...

So, there is no point.

Whatever you say, they will usually say: books say differently, or our experiences with 100s of patients about that drug are different. It is all in your head and you probably have anxiety.

Your mom could have passed away from 100s of reasons.

But also, if she was old and with a weak heart, then yes, quitting BBs could have caused a huge stress to her body.

I mean, it could happened even on drugs, but with quitting them abruptly, imo, docs have raised a risk for an incident.

One doc told me: take BBs (1,25Mg dose) whenever you need. It's like taking a candy, it is a very weak drug.

And then you have 1000s of people to whom even the tiniest doses ruined their lives.

Again, I am sorry for you, but there is not too much what any of us can do. You can listen to docs, listen to your body and your logic, and listen to people who had similar problems and then taking something from each 3 sides and decide what is "true".

 

Karen, plus, I will add more:

1. if you have too high heart rate=you can die since your heart is beating too fast

2. if you have too slow heart rate=you can die from long pauses between beats, or long pauses can create deadly arrhytmias from which you can again die

So, for example, if someone is taking BBs for some heart disease (NOT tachycardia), like coronary artery disease, high blood pressure etc, there is a chance that this person usually has a normal heart rate, but will now develop a too slow heart rate.

So, maybe your mother had too slow HR due to Beta Blockers and docs thought that they have to quit it right away since there was a chance for a sudden death from too long pauses (especially during sleeping).

So, for example, in a situation like that, options are:

1. if you stay on BBs=there is a 50% chance that you will die from a too slow heart beat (long pauses between beats)

2. if you quit BBs abruptly=there is a 10% chance that you will die from a withdrwal

I want to say: there are 1000s of scenarios and 1000s of different diseases and side effects.

So, it is possible:

1. that your mom had an original disease=and she would die without Beta Blockers or a similar drug, so she needed to take drugs

2. drugs caused a dangerous pauses from which she could die=so they needed to quit it right away

3. quitting drugs abruptly can kill an older person easily=but again, they had no choice, and that seemed less likely (especially since docs think that quiting BBs is not too hard)

I wanted to say: docs think that quitting BBs isn't dangerous, but also: in some cases you can die without Beta blockers, you can die BECAUSE of Beta blockers, but you can also die if you quit them. So, whatever you do, you are in huge problems (and you can die, sadly).

And things can easily go wrong in 100s of ways, sadly.

Dear Rachel,

I have just been doing a little research and I saw your post and it caught my attention... I am truly sorry for you're problems both with BBs and the initial cause...

I would just like to say though that personally I found out just before my birthday that I had AF (Atrial Fibrillation), I had an attack which my EX GF noticed that my heart was beating out of my chest... after a lot of persuasion I went to the hospital due to history of heart attacks in the family,

I spent 2 weeks in high dependency unit as when I arrived at A+E my resting HR was 180 Bpm- 236 Bpm (that I saw)!!!

I'm now stuck on Bisoprolol and my "specialist" reduced it from 12.5mg daily to 10mg... my next birthday about a year later I am back in hospital with the same issue.

I'm just trying to say that you are not alone and you are always entitled to 2nd, 3rd opinions... at the end of the day it is YOUR life, you have to live with it not some of these (not all) pompous doctors etc.

I have no fear of anything and I don't say that lightly I never have a fast HR now (unless from exercise) ... I have no fear of pain, I.E I cut the end of my right index finger almost clean off and I hardly blinked and drove to the hospital, I am wondering if from the other comments I have seen regarding Adrenaline if this is normal????

It's not just that, I got knocked over by a car a few months ago (only at 20-30mph) after landing on the floor I was quite badly injured (says EX) but I decided that my paperwork was more important and just walked away and left it at that.

I'm concerned I may end up accidentally doing something that I might not be able to walk away from or something similar!

I hope this makes sense...

1. I really feel for you and understand (as much as possible)

2. I hope you get this resolved!!

3. I would like to know if anyone else has had any similar experiences I.e no "fight or flight" adrenaline

4. I am soooo cold!!!! Do BBs MAKE YOU cold?????? I know it's a bit of a daft question but I am always really really cold, it has got to the point where I'm constantly wearing a thermal outfit, then layers and layers of clothes and try to avoid going outside if it's not nice weather (more than avg. person) I don't know what to do, haven't seen cardiologist for about 10 months now...

Does anyone else feel cold from BBs (Bisoprolol) mainly.

I'm doing a little research regarding your situation but you have had some excellent unbelievable responses!!! However I think all helps helpful, even a little! :-)

Best Wishes,

P.s Thank you in advance for any responses I receive!!!

Hi, about your "no fight or flight" adrenaline, well, that is one of the purposes of Beta blockers.

To some extent, they make you "dead" and calm all the time.

Somewhat similar to Valium, for example, except that BBs have much stronger effect on heart and blood pressure than Valium.

For example, without BBs, a normal person will have a resting heart rate 60-70-80.

During excercise, HR will go to 120, 150 and similar.

When you are too excited (for example, watching sport, movies etc), your HR will go up too.

Now, if you are prone to tachycardia, arrhytmias and similar, those are often triggered by excercise, stress, too high excitement etc.

When you take BBs, they will block your emotions and HR of going into extremes.

Let's say that for a normal person, you will go to -100 level (of your emotions) when you are scared, stressed etc.

+0 will be a normal level.

+100 will be when you are too excited about some activity (let's say watching an important sport match).

So, for a normal person, emotions (and thus HR as a response to your emotions) will go from -100 to +100 in everyday life.

When you take BBs, they affect your Central nervous system and lots of mechanisms in brains (which eventually slow down our heart and block extreme emotions), so this way, your emotions won't go from -100 to +100 anymore, but more like from -60 to +60.

So, roughly, on BBs, you can never get as excited or as scared as a normal person. You are numb to some extent.

You won't go into extremes with emotions, you will always be closer to zero (or around a middle, when you are neither sad/scared/happy/excited)

That way, BBs are trying to prevent triggers of arrhytmias, like too much excitement, stress etc.

But also, this way BBs will slow down your heart all day long, they will protect your heart that way, plus even if you do get an episode of arrhytmia, it shouldn't last that long, and your HR should be lower during an episode than without BBs.

So, BBs have a lot of good sides and they protect people in 100s of situations.

But again, they have lots of side effects, like this emotional numbness which you have described (and I have experienced the same when I was taking BBs. I never enjoyed sport, music, love life or usual things that used to excite me, during taking BBs. For example, I was watching important matches of my team, and if my team was winning, I would just say: ok. If my team was losing, I would just say: ok.)

About how you are feeling cold, well, BBs are slowing down our hearts (Heart rate) and amount of blood pumped in each second, and thus less blood and oxygen will flow around our body.

Also, in legs, arms (especially feet and fingers) and parts of a body which are further from the heart, you will get the lowest amount of blood and oxygen (weaker circulation) and those parts can easily get cold.

For example, I used to have cold feet and hands all day long.

When I was shaking hands with people, they used to ask me: omg, why do you have such a cold hands (in the middle of a summer)?

And I was taking only 1,25 and later 0,62 Mg of Bisoprolol.

My dad takes a lot of medicines for high blood pressure, and BBs are one of them.

He is feeling cold all the time.

For example, all people are saying that it is extremely hot and they are sweating, while my dad has long sleeves all the time and just saying: I'm cold. It's quite cold today...

Since you are on a largest dose of a BB (10 and 12,5 Mg), it is understandable that you have these side effects.

Good luck

Hi Bob,thankyou for your rely, I understand what you are saying about the many senarios.  I am still of the opinion that they did not explore the benefits or dangers and maybe should have returned to her dose of 1 tablet instead of 3.  They didn't explain anything and did not monitor effectively after.  We trust them explicitly but with hindsight we should go with ourv gut sometimes.  It just seems too conincidental that it happened 2 days later.  she also experienced this feeling of extreme 'breathlessness' that everyone is talking about.  Ultimately it was too much for her, if they had have monitored her more i feel if could have been prevented even for a short time and she woould not have suffered.  Thank you for your knowledge and I will continue, as you do, to fight inprder for them to isten.

This discussion has been super helpful. I've been taking 2.5 mg Bisoprolol daily for about 9 months and started getting off about 3 weeks ago. My doctor told me I didn't need to taper much because my dosage was so low. He said 3 days at 1.25 mg should be enough. I was mostly OK after during the first week of withdrawal but then symptoms described in this thread had hit me hard - rapid heartbeat, feeling lack of air, some nausea, chest tighness, palpitations. Fortunately I read this discussion before and knew what to expect. Still one particularly bad night I considered going to emergency.

3 weeks after getting off I feel much better. Palpitations are mostly gone and I have way more energy toward end of each day. However when I try to go running, my heart rate is still quite a rollercoster and that causes a lot of anxiety. This isn't something completely new. I've had these sudden sharp increases and drops of HR by 30-40 bpm when running before. That was one of the reason I was put on Bisoprolol in the first place. When I was on Bisoprolol I still had these occasional spikes but they didn't completely prevent me from running. Now 3 weeks after getting off, running is nearly impossible. HR might go up from 110-120 to 150-160 instantly on almost no effort and then drop down as sharply when I stop running, then go up again, and down again. It is very frustrating. I wonder if there are any runners or people who excercise reading this discussion and if you've experienced something like this and if that is supposed to get better with more time off beta blocker.

Hi, Stan

About running, when I have quit BBs, I had a too high heart rate much longer, so I didn't even think about running.

I was happy just to be able to walk every day.

And each new day I would try to walk longer and longer and after a few weeks: faster and faster.

Imo, you are not done yet with a withdrawal and docs say to avoid a strenous physical activity during a withdrawal because you can get a heart attack.

Imo, maybe you should start with walking.

Go out and walk 30, 45, 60 minutes each day.

If you will be fine, try to walk more and more and faster and faster. After a few weeks, when you will be completely fine after 60 minutes of fast walking, you can try to run again.

Beta Blockers mess with our heart, brain, lungs, blood circulation, levels of oxygen and food in our organs and over the whole body.

Your heart is still in a mess, blood vessels alos, lungs are working at 50-80% probably due to Months on Beta blockers, your organs have been getting lower levels of blood and oxygen for Months.

It will take a few Months until your body will be normal again.

So, imo, please, slow down your excercise.

Try to walk a lot, and do some stretching excercises at home for the beginning.

And if you are so desperate about running, then start with: 30 minutes of walking and 2 minutes of running on a day 1.

Then 30 minutes of walking and 5 minutes ot running after a few days etc.

Don't run right away, give your body a chance to readjust (to walking, for the beginning).

Even though you think that you are fine, your blood vessels are still under the effects of Beta blockers and your body surely hasn't relearned yet how to live and run under these new circumstances.

So, do it slowly and give it some time.

Good luck

Hi Bob,

Thank you for your reply! I've been running at least 10-15 miles per week through entire time I was on Bisoprolol. I am walking a good amount every day, usually at least 10000 steps and it feels like doing other activity is generally OK. Even when I attempt to run if I didn't look at HR monitor I probably wouldn't know there was a problem. According to what my doctors said me structurally my heart and vessels are in great shape. I was running ultra-marathons before I got ill. It seems it is "electrical system" that gets over-excited and fires prematurely, and adrenaline overload is probably the culprit. To make things worse my thyroid system is under-active and that might be another reason for the body to try to compensate lack of energy with releasing more adrenaline. It feels like physically I am capable to run but my nervous system "thinks" otherwise.

But you are completely right that I still should take it slow and increase the load very gradually. I need to calm down my nervous system so that it stops releasing so much adrenaline.  

Hi,

I was taking Metoprolol ER for about 1 year (12.5MG).  My doctor told me that I could stop taking the medicine because it wasn't helping with my PACs.  I stopped this medicine cold turkey on the advice of my cardiologist who said 12.5 MG is a very minimal dose.  I do not have high blood pressure, in fact it is never above 115/70.  The sole purpose for the beta blocker was to see if it would help with the PACs which it did not - in fact it made them worse.

I stopped the medicine a month ago and have been on a roller coaster of a ride.  I'm trying to see if my issues right now are from withdrawal as I never had any of these symptoms before taking the beta blocker.

I do not have these symptoms all day, they come and go.  

1. I get dizzy ( the room is NOT spinning - I just feel off balance myself)

2. My legs sometimes feel very weak

3. Lightheadedness and shakiness at times - especially if I'm hungry (I've checked my blood sugar and it is within the normal limits)

4. ANXIETY like I've never had before- almost like a panic feeling for no reason.  I did not have this prior to beta blockers

5. Upset stomach that comes and goes with loose stools which I am assuming is from the extra adrenaline as I used to always have to go to the bathroom when I was nervous before beta blockers. 

I have talked with my cardiologist about this and he was very vague and said it could be from withdrawal and that everyone responds differently.  I recently wore a 14 day holter that showed everything is ok with my heart.  I've had the stress tests, echo, etc and it all shows my heart is healthy with a lot of PACs which are actually a lot less since I am not taking metoprolol.

If anyone can shed some light on these symptoms and how long they may last I would appreciate it greatly.