I have tried many anti depressants over the years. I started Sertraline 8 weeks ago, started on 50 then went to 100 a week later. My anxiety is still high and feel I am not progressing. Mornings are the worse. Then after lunch I tend to settle. I also get the tremors/shakes. I spoke to my GP about changing to something else. I am going to change over to Pristiq. So going to take both Pristiq 50 plus Sertraline 100 , then over a few weeks gradually reduce the Sertraline and eventually increase the Pristiq. What I would like to know, has anyone had no success with Seretraline and changed over to another? I feel after 8 weeks I should be seeing some improvement. thanks S