Cryoglobulins are immune complexes that precipitate at temperatures lower than 37°C and are deposited on vascular endothelium, causing vasculitis in organs such as the skin, kidneys, peripheral nerves and salivary glands. Cryoglobulins produce organ damage through two main pathways - vascular sludging (hyperviscosity syndrome, mainly in type I cryoglobulinaemia) and immune-mediated mechanisms (principally vasculitis, in mixed cryoglobulinaemia).1Manifestations vary according to type and range but the classical triad (Meltzer's triad) is purpura, weakness and arthralgias.
This is a companion discussion topic for the original article at https://patient.info/doctor/haematology/cryoglobulinaemia