Cushing syndrome after long antibiotic usage?

Hormones
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I had a surgery 4 years ago (minor) and was infected wih Klebsiella Pneumoniae in the hospital. I was terated with different type of antibiotics over 2 month to get rid of it. I was not the same person after this. I had burnng stomach, high blood pressure, gainig weight, fat in legs and face, sudden Barret, etc. I was completely health  person prior the surgery. I was going from doctor to doctor trying to understand what happened to me. Few weeks ago I was diagnosed with Cushing syndrome. I wonder if anybody had the same experience as me - Cushing decase after few years of severe infection treaten by long period by antibiotics.

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Just to say well done you.  I have been trying to find a common denominator for those who get Cushings but no luck so far.  I will try to think back and I hope the other members will answer you too.  At least now you know what is wrong.  Take care and I will respond again soon.  Any thoughts Debs or Gill?

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Hi Vicky. thanks for the reply. I met another person in hospital who was diagnosed with Cushing in age 19 after he was treated by antibiotics for a month in hospital and told me hte same story

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Hi, I can't link this with anything that's happened with me. As far as the antibiotic treatment is concerned,it sounds like the treatment may have had steroids in it,possibly?

If this is the case,then the steroids would have caused the adrenals to be overactive ie the definition of Cushing's. Having stopped that treatment, though, wouldn't the levels have gone back to normal? I can't see why this treatment would have caused Cushing's DISEASE, from a pituitary tumour, like I had, and you I think, Vicky?

Sorry can't be of much help. Gill

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Gi Gil, The reason I asked is the following:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892578/

Invasive fungal infections in endogenous Cushing's syndrome

http://www.ncbi.nlm.nih.gov/pubmed/1814913

http://www.researchgate.net/publication/265730832_Candida_albicans_endophthalmitis_in_a_patient_with_a_non-functioning_Pituitary_Adenoma_Evolving_into_Cushing's_Disease_A_Case_Report

I had very strong candida infection after antibiotic treatment. I was wondering if there are other people who had Cushing evolved after Candida. Candida appeared after antibiotic treatment.

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Hi,  I see that Gill has replied to you.  I have been checking up and I was on Antibotics (Septrin) for years because my then GP thought I had a kidney problem.  Eventuall my new GP gave me a kidney xray and it turned out I had spinal problems so came of the antibiotics straight away. I understand that Gill hasnt had the same experience.  I did have a tumour on the Pit Gland but to be quite honest it is such a horrible disease that I wouldnt be at all surprised if the antibiotics had something to do with it.  Im not sure if Septrin contained steroids.  Did yours?  Thanks so much for your input.  Vicky

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Hi Vicky, I was taking different groups of antibiotics, since I was infected with virus resistant to antibiotics - Klebsiela. I will check with my doctor regarding streroids. I found so many articles regarding fungal infections evolving in Cushing patients in US National Library medical articles. I was wondering if the Candida comes after antibiotics treatment and evolves in Cushing. There are few cases describing this too. So the reason I asked about antibiotics was further Candida and further Cushing. I am not claiming that this is the only reason. But according to researches not everybody who goes through surgery has tumor found.

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Hi Irene,

I honestly dont think the medical World knows exactly what causes cushings. The main reason being is that everyone who is diagnosed has a slightly different story to tell. I hadnt even thought about antibiotics as a " possible ". I had Micoplasma Pneumonia and was on triple antibiotics for about 10 weeks. I also had Helicobactor Pylori which required triple antibiotics. There was no steroids in my treatment so i cant see how that would have caused my Cushings.

I differ slightly from the other girls here in that i didnt have a specified tumor on my pituitary gland. I had Diffuse over abundance and hyperplasia of the ACTH cells in my pituitary gland. This resulted in the surgeon having to remove all of my pituitary gland exept a very small piece that attaches to the stem leading to the hyperthalamus. I am 20 months post surgery and my cortisol has been sitting on a very stable 960 ( normal range 118-619 ). I used to stress about it remaining high as some of the doctors i was seeing kept asking me what " I " was doing to keep them high !!! They asked me where i got the prescription for the hydrocortizone !!! Darn right rude if you ask me. It got so bad i was {} this close to killing myself. Anyway, at my last visit I asked the doc what my levels were and he said unchanged, still around 960 ( 964 to be exact). So i said is it possible thats just a normal level for me, he responded, its highly likely(he is my nicest doctor, he never blamed me or insinuated i was doing something to raise my levels ). So after that visit i decided to stop stressing about it, i just dont care anymore. I am exercising and eating healthy, thats the best i can do. Hopefully that will be enough to counteract the high cortisol. Hopefully i will remain well. I am certainly better than i was pre surgery. My levels were Over 1200 then. My blood pressure is down a little ( not there yet but working on it and same for my sugars. They are good, but im on lots of medication to maintain it. So i guess in response to your question, anything is possible, probable and who knows cos the medical world certainly dont know ( Hopefully they are learning more with time).

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Thanks Irene.