I had a unexplained calf pain a few years ago that was a DVT missed by both the doctor's exam and ultrasound. It turned into a PE a few days later. I was admitted to the hospital with a life threatening PE and then put on warfarin for life.
I had blood tests to check for Factor V and other clotting disorders and they were all negative. The doctor said that warfarin is permanent despite not having family history or positive lab tests for genetic disorders because the clot was unexplained. They questioned me about having taken any long flights or road trips shortly before the DVT but I couldn't remember anything, so I said none of that happened. There was a long road trip, but it was several weeks before I had any symptoms.
For whatever reason, warfarin is processed out of my body at a high rate, so the effective dose for me to be in the therapeutic range is extremely massive. I have never heard of anyone else taking 30 mg daily (2.1 grams per week).
I now remember something that likely initiated the original DVT. There was no flight, but I remember working at a desk before rge calf pain started and being so busy on the phone that I lost track of time and missed lunch and didn't get up to go the restroom.
I had never mentioned this to the doctors, because I couldn't remember it at the time
This is years later now, but since there is now an explanation for the DVT, I want to get off of Coumadin and just take extra precautions to not sit for hours at a desk or on a flight without getting up again.
Despite being negative for all clotting disorders in lab tests, my medical record is marked with having clotting disorder in a generic way because I had an unexplained DVT which became a PE.
I wonder if I should bring this up now and try to get off Coumadin? I feel like there may be more health risk for me being on massive doses of warfarin for the next 30+ years than there is risk for future clots now that there is an explanation for the original DVT.