Hi, I had a feeling that this day was coming. Because I am on Oriencia I developed Psoriasis. I asked her to lower the dose of Oriencia to see if it got better, it did not. I just had my blood taken and my inflammation numbers are up and now she is talking about changing biologics. I am currently on 10 mg. MTX and no pain pills or prednisone. At the present time the only pain I have is my knuckles hurt. I am due my infusion tomorrow. I have been on Remicade and after a year it stopped working. While on Remicade I was on prednisone and pain medication. Oriencia has been a life changer for me and after looking at all of the other biologics I just do not see one that is going to work. Oriencia is the only biologic that helps with the selective T Cells, no other biologics do that and I feel that if the other drugs don’t do that then they will not work and I will be back on prednisone and pain medication. Unfortunately I live in the states and my Medicare will not cover shots or pills, what a delima Everything I. Take has to be an infusion. Retuxin scares me to death, Actemera can causes heart attaches and the only thing left is to go back on Remicade. I really don’t know what to do. I am almost positive that to take any of the other drugs that my days of no pain and no prednisone are short lived. The question is this, has anybody been on a biologic and had extremely good results and because you get some other autoimmune disease while on the medication and then had to go off and put on another biologic how. Did that work out.? Did you stay the same, get better or worse? I am so upset because Oriencia makes life wonderful and now because It caused the Psoriasis I have to get off. I really hope someone has some experience along these lines.