Does anyone get bad agitation/anxiety with depression

I can't seem to cope with terrible agitation. Can't seem to calm myself down. Anyone the same?

Yeah.  Mine is a vicious circle,  I get anxious which makes me. Depressed then get anxious be because I'm depressed! 

Yes exactly the same ,are you on meds.

I cannot take them,which makes it worse or does it.

 

Thank you for your replies. I am on a concoction of meds of which don't seem to be working. Why can't you take any medication?