Fluoroquinolone Toxicity Syndrome

This is a discussion for users who wish to specifically discuss Fluoroquinolone Toxicity Syndrome. You can add your history here and there are some resources listed below that may be useful.

https://www.nature.com/articles/d41586-018-03267-5

Article published in Nature magazine about Fluoroquinolones and the reasons why they can have such devastating side effects.

http://www.emedexpert.com/lists/antibiotics.shtml#5

For a list of Fluoroquinolone antibiotics

http://www.quintoxsupport.co.uk/

Quinolone Toxicity Support UK

http://floxiehope.com/

A site for those who are suffering from Fluoroquinolone Toxicity Syndrome as a result of being adversely affected by fluoroquinolone antibiotics – Cipro, Levaquin, Avelox, Floxin, etc. 

www.saferpills.org

Quinolone Vigilance Foundation

https://www.facebook.com/groups/quinolonetoxicitysupportuk

Closed Facebook group for UK users.

https://yellowcard.mhra.gov.uk/

If you think you have had a side-effect to one of your medicines you can report this on the Yellow Card Scheme.

http://www.adrreports.eu/en/index.html

European database of suspected adverse drug reaction reports

http://www.fda.gov/Safety/MedWatch/default.htm

FDA MedWatch: FDA Safety Information and Adverse Event Reporting Program

http://www.fda.gov/Drugs/DrugSafety/ucm500143.htm

FDA Drug Safety Communication

Many thanks for this. It's much appreciated.

Plodding on

As well as many other side effects, joints, brain fog etc, I was out in my garden for 10 minutes, I had jeans on when I came indoors my legs felt like they were on fire and my tongue has gone tingley, I took my jeans off and I have what looks like severe sun burn all down them, I know this is the cipro has anyone else had this??

Glad to see the link worked for you :-)

As you've already seen my reply I won't repeat it.....

 I will say again though, I hope all these ADRs settle down soon. Maybe, stay away from the sun; a pain I know but you can do without this extra burning which must be an effect of Cipro and sun.

Very warm wishes 

Carol

Thankyou again Carol. I have a question!! when people say about brain fog what is it? I have a light headed almost dizzy feeling most of the time, I haven't drunk alcohol for a few years but from what I can remember I would liken it to the feeling you have when you are starting to feel the effects is this brain fog?? kind regards Gayle

I take it as meaning those feelings you describe, plus not being able to think clearly, not being able to concentrate, struggling to find words, not being able to make sense of something or to do the things you normally do with ease, like planning something or collecting your thoughts in a logical order. Also not being able to complete tasks that require ordering your thoughts eg, writing or even being able to finish a sentence. You might forget what you started to say or forgetting what someone else has just said. You might not be able to concentrate on a TV program or read a book. Feeling fuzzy or befuddled...

Does that make any sense?

Carol

Yes makes sense, mine is more of the lightheadedness and feeling not quite there, albeit I was in the chemists earlier to report to them what had happened and meant to look for iron tablets and couldn't remember what they were called which was slightly embarrassing. The woman who took the details said they had been discussing cipro and its side effects last week! More has to be done to alert people to these awful drugs.

Sounds like you do have a bit of brain fog :-(

Just to to have this heading for discussions here is a major step in the right direction, as the GPs use this site and direct patients to it, so it means that for those who have been 'floxed' (I hate that word but don't know what else we could be called) and whose docs don't believe them, perhaps they can now direct their docs to these discussions. It's a start anyway.

when I was first Floxed just over two years ago, I looked here and there was no recent activity but when I looked in again months later, there was some and more people are finding these discussions now. I wish there weren't so many but it's a fact that millions of people have been and are being affected.

All we can do is to tell friends and family and anyone else who will listen and hope for the cascade effect. 

Carol

Hello all, 

I have been looking for an active thread rather than one that hasn't been replied to. I am in desperate need of some adivce and guidance. 

Please bear with me while I fill you in but I will try to keep it as brief as possible. 

I'm a 31yr old male, uk

I was diagnosed with a suspected uti in december of last year following a cystoscopy and prescribed 1 month of trimetoprim and sent on my merry way. The infection cleared and I had no side effects. A month later around Febraury I ended up back at the doctors with suspected prostatitis. A consultation with a urologist confirmed this apparantley and he gave me 6 weeks of 250mg Cipro. 

I took it for 3 weeks before the side effects became unbearable so I stopped. I went back to the original consultant who performed the cystoscopy. There was an admin error at the hospital hence they sent me to another urologist rather than the original one. 

I explained the side effects I had suffered since taking the cipro aswell as the fact the suspect prostatits symptoms continued. He ordered a ct scan of all the lower abdomen as well as an ultrasound of the groin area. This was start of May. Everything came back fine.

Full blod count twice. Nothing significant. 

ever since taking cipro I am deteriorating daily, suffering from the following: 

dizziness- feeling unsteady on my feet. Can't walk in a straight line.

Chronic fatigue. I can not get through the day at work without sleeping. I dont feel refreshed upon waking. Im a walking zombie. 

Muscle weakness and spasm in legs/ arms. Sometimes i have no strength left in my hands. I have to exert myself in every small task.

Fluctuations in body temp- sometimes temp rises so rapidly I almost collapse.  

Shortness of breath and axiety 

ramdom muscle pain and joint pains which were really bad couple of months ago but have subsided somewhat. 

Confusion- I make mistakes while type. I can't concentrate long. I have a heavy head through the course of the day. I've been suffering from bad headaches in recent weeks aswell. I do suffer from myofascial pain of the shoulder but I know when a headache is due to shoulder pain. 

I did notice a red rash on my arm and leg appear while in the shower a couple of months ago which was not painful or itchy to touch. It dissapeared. It did not look like the bulls eye rash you get with lyme disease however. 

I have just submitted a yellow card with mhra and I have made an appointment to see a private colsultant who is a specialist in chronic fatigue syndrome. He diagnoses using blood test however i am unsure if this is the right path to go down becuase I dont know if this is cfs, or cipro posioning. I am sturggling financially and don't want to end up paying for the wrong diagnosis.

so thoughts please? have i been 'fluoxed' or is this cfs. What step should I take next. I have an appt with my gp next thursday. I need her to take me seriously.

Thanks in advance

CLix

Hi Clix

I can't tell you how sorry I am to find you here and suffering so badly, with what is clear to me, quite a severe adverse reaction to the Cipro.

Your story is very common. I have heard of Cipro being used often to treat Prostatitis and it doesn't work for this.

It's good that you've managed to report your ADRs on the Yellow Card Scheme - It's hard work when you've got brain fog and everything else.

Chronic Fatigue Syndrome has been linked with and mistaken for FQT very often. I would go so far as to say that you haven't got CFS but it's the FQ poisoning, though I'm no medic. Having said that, the majority of doctors don't recognise FQ Toxicity syndrome. They can't believe that one could have so many side effects from the FQ, as many are listed as 'rare' or 'very rare'.....which they are not! Nor can they understand that FQs have an ongoing reaction, cascading throughout the body. It's systemic and the docs think that after a few months the antibiotic will be out of your system; wrong, it's action becomes a chain of reactions. Also because ADRs can be delayed, not manifesting for maybe months after stopping the FQs, the patients and doctors, don't make the connection and therefore don't realise they've been 'Floxed'. We all join up the dots in the end...us who have taken these sledgehammer antibiotics, not the doctors.

Many Floxed people end up doing the rounds of all the various health departments, searching for concrete evidence of something and usually to no avail. I had an ultrasound of my Achilles and feet and it did show abnormalities which couldn't be explained. The Consultant Radiologist asked me whether I went running regularly, or a keen walker, as this would explain the things he could see that were wrong. I have never gone running or been a keen walker and told him it had to be the Levofloxacin. He didn't argue at all; I explained the action the drug has on collagen and he asked why it was being prescribed so inappropriately and was appalled at the ADRs.

You need some hard facts and information about FQs to,take to your GP and so I suggest that you try to follow links to info. Start with Floxie Hope (the link is above in the Moderator's post) Lisa explains the action of FQs very well and makes it easier to understand but she also backs up what she says with links to Scientific papers etc. You need to get your GP to understand that all your symptoms are ADRs. So print off stuff to leave with him but first try to explain it yourself. Take all the time you need too and don't worry if your appt overruns, is my advice. I have met hundreds of FQT sufferers over the last two years and I know of thousands. You can tell your GP that ther are Class Action Lawsuits going on in the U.S. but don't let him think you are going to sue. Also there have been a few dozen items on the major US TV News channels over the last few months. Each time a story ran, the stations were inundated with people getting in touch because they had been poisoned too. FQs have two Black Box warnings on the labels in the U.S. and this is what happens before a drug is eventually taken off the market.

Sorry I have waffled a bit here.

Rest and sleep when you have to. Get some Epsome Salts to bathe in and take Magnesium too.

Let us know how you go on and please ask if there's anything you want to know and I'll try to help if I can.

Take care...oh and btw you will get better, though it may take a while.

Carol

 

So sorry you have been poisoned too, I was floxed April this yr and feel like I'm in a living hell. This drug is so dangerously toxic and should not be prescribed. As carol said floxie hope is a great site for support and information. I too have the dizzy lightheadedness, I also have widespread tendon pain and creaking, my knees are agony and I find it hard to walk, I have developed tmj and tinnitus aswel as digestive problems and cns damage. I have been unable to work for 6 weeks now. Please do keep in touch and look on floxie hope.

Hi Ploddingon

Thank you so much for the prompt reply and information. So reassuing to know that I am not alone and there is someone who agrees with me and that it's not just some figure of my imagination. 

I will have a read of the website you mentioned to gather some proper information on FQT. 

Question if by some miracle my gp does take into account what I have to say. What then? Everyone talks about the side effects of cipro etc but i havent really read of any get well stories and what they did? 

Since this whole saga recently I have been complaining of lower back pain and testicular ache so I had another ultrasound done of the groin area about 2 weeks ago. I expect everything is ok otherwise I would have heard from my gp. I suspect this is epididymitis. 

I also think my ibs is back with avengance after a few years of restbite as I am unable to retain any food. 

I was doing so well in the last year after recovering from the shoulder injury. Everything has just gone to shi*

I'm not sure  I can keep up work for much longer in this current state. I am at breaking point at the moment because I am literally kicking myself for listening to the consultant and trusting him. Usually I look into things before committing but I guess with everything in the last 6 months I was desperate to get better. Sorry for the rant. 

I too regret not looking into what I was taking, but we trust our Drs and never even in a horror story could I imagine that a drug like this could exist. I have never suffered from digestive problems but since being floxed I can't retain food either and am not digesting it. We can only hope that with time healing will come. I am on Magnesium and other supplements but not sure they are helping.

Hi Clix

You're welcome :-)

No you aren't alone - there are hundreds and thousands of us, all over the world (I've talked to FQT victims from many countries) and you're not imagining it, or going crazy either, though you probably feel you are.

It's a massive shock in so many ways, to realise what's happened. I was in shock and disbelief (apart from the severe pain and other weird symptoms, which would appear daily) when I joined up the dots on about the 5th day on Levofloxacin. Even then I continued taking it, as I couldn't believe it was true. My GP was visiting me at home because I was so unwell and I couldn't walk and she was met with a hysterical and frightened woman in bed, surrounded by iPad and loads of printed material about FQs and completely freaking out. Neither of us knew what to do but at least she didn't doubt for a minute what was happening to me and I have had her total ongoing support.

I never took or did anything specific to help my recovery, apart making a huge mistake and going to a Physio for a few weeks, once I could walk a bit, after 5-6 months in bed.bI had tried to explain to the Physio that this tendon damage wasn't like a sports injury and that the collagen was breaking down all over the tendon and it's structure had changed; it was a case of whether the collagen could repair faster than it was breaking down and also that the strands of new collagen would grow back higgledy piggledy and not in an ordered way, as before. Long story short, I was given different strengths of resistance bands to use, over a period of time but it was a disaster and I made everything worse, plus there is always a risk of the tendons rupturing. I was better left to my own devices and moving a little but rearing a lot. 

In the end it was time and listening to my own body that helped me and reading stories of people recovering too. There are many horror stories out there and it's easy to start to think you will never get better; then the panic sets in. You will find stories of recovery on Floxie Hope :-) Lisa Bloomquist (Floxie Hope) has an ebook by the same name, on Amazon and it is very inexpensive, easy to read, short and full of hope. I recommend it.

Many people say they are helped by taking Magnesium and also Glutathione IV (I think it's spelt like that) seems to be gaining favour in the US but I have no idea how one would go about getting that treatment here in the UK.

You need to try and eat healthy but there are some who say that Soy products and Dairy should be avoided. I lost my appetite completely and also much weight and two years on I'm still very underweight with muscle wasting too (I am still about 70/80% better though) You may find that you can't tolerate certain foods that you normally have no problem with and digestive problems are common. In your research you will discover that every system in our bodies can be affected, ranging from physical to neurological.

Look for The Flox Report; it is worth reading.

We all feel stupid for taking the poison and me especially, for continuing to take it for a further 4 days, after I began to learn I had a big problem with it but still couldn't believe that an antibiotic could do this. We are not to blame though, as we put our trust in the health professionals who prescribed it for us. My GP had been advised to prescribe it to me by a Specialist Nurse. Unfortunately, they don't know what they should about FQs ie that they are never supposed to be used as a first line defence. There is even a UK government directive to this effect! 

If you can make your GP understand what is happening to you (and I'm sure you can with the back up info) then she should be able to sign you off work, because it sounds like you are getting to the point, as you say, when you feel you can't continue working. Many FQT victims have to take time off. I wasn't working, so didn't have that added stress. 

You need to rest and try and avoid getting over stressed, even though anxiety is another ADR.

Btw, if on Floxie Hope you can find a ' Letter for a Doctor'( It's been written for FQT sufferers to take to their Docs) it's worth printing off, also a letter from a Doctor to Michelle Obama, explaining about FQs. I have these if you can't access them, so let me know and I'll search for them and send them to you, if necessary. 

Don't beat yourself up for taking the Cipro. You should never have been prescribed it and from now on you'll look everything up first but when we are very ill, we rely on our medics to do the right thing and not to harm us further.

Rant away as much as you want.

Carol

 

Hi Gayle

It's good to hear from you again and my heart goes out to you, as I can imagine how bad you feel. It is hell but you just have to keep going through it, with the belief that you will get better.....eventually.

I've lost two years of my life to this and I'm still not out of the woods yet. Trying to explain to people becomes a nightmare too and some friends have virtually given up on me now, as I've had to refuse so many social occasions but I haven't the energy to go anywhere or do anything really. Even though I can now walk a bit, my Achilles and all the original tenons affected still ache and also my bones and muscles too. I haven't been able to wear a normal pair of shoes or snappy little boots for over two years now. I live in slippers and can only wear wide, soft suede boots to go outdoors in...not great in the sunshine and heat.

I still have insomnia and I forget what it's like to sleep for more than a couple of hours at a time. If I get 3 straight hours, I think it's a good night! I have given up even trying to sleep at night now and tend to drop off as it gets light. I fall asleep all the time during the day though.

I'm depressing myself now!

At least we can talk to each other here. I've given up on the FB groups; they were useful at first for info but they are toxic now and best avoided.

We are in this together. Hang on in there Gayle.

Carol

I think the letter to give a doc is titled 'Dear Doctor'.

Perhaps I should list all of my ADRs here too, then we could direct disbelieving GPs and other docs, to these discussions. After all, they use the site and direct patients to the site for info. Maybe it's time they looked at the forums also......

Sorry for all these additions...wish we could edit posts!!!!

A big thing to get across to docs et al, is that just because a side effect is listed as 'rare', or 'very rare', it doesn't mean we haven't got it and why should it be assumed that we can't have more than one side effect (I use the words in the Patient info leaflets)? Many of our ADRs are actually listed as possible reactions in the packet inserts but they are written in such a tiny font and without highlighting the most common ones, they are easy to miss.

Many of us (I was) were given steroids or NSAIDs concurrently and both are listed as contraindications with FQs

I must stop rambling....I get angry!

Carol

Hi Ploddingon

Apologies fo rthe slight delayi n replying but my computer was playing up and after the last reply I didnt have any energy so fell asleep. I will have to read over what you have said in the thread a couple of times for me to absorb it in. 

Today is a really bad day unfortunatley. My stomach has been really bad since this morning so had to take an immodium tablet. Feeling very unsettled and was hyperventialting earlier so I checked my blood pressure which was 114/72 which I read is within the normal range but usually im a little higher. 

So other than taking magnesium is there anything else I should do in the meantime? 

Based on my symotoms what is the best course of action in getting better. I know  there is no magic bullet as everyone has different ADR's i.e. you had achilies tendon. Mine is more hormone and neurological based I guess. 

If you have that letter to hand you mentioned I would be greatful. 

Thanks

Clix

Thankyou for your reply Carol, it is a lonely dark place being floxed, it is hard for me to believe it has really happened let alone anyone else. My Dr believes me about the tendon and joint pain but doesn't want to acknowledge the other adrs, like you I am already of slight build and can't afford to lose the weight I am. My head today has been somewhat clearer at times but I have a new adr of my heart racing for no reason. We need to support each other and get the word out there as they have started to in America.

Clix - Please don't apologise for not replying sooner. I only have short bursts of energy, when I feel I can do something.....and that's usually doing something on my iPad, whilst lying on my bed. Most of the time I haven't the energy to do even this. Maybe that's why I write such long posts (sorry) to catch the wave, whilst it's here; also I keep thinking of more things to tell you about and it all just pours out in a bit of a jumble I'm afraid.

I will find the letter and anything else that could be useful to show your GP and send them to you as a private message, or if you want to message me your email address, I'll send them that way. As soon as I find the letter, I'll send that alone though, as all my notes and research is all over the place and it might take me a while to sort.

Whilst the major ADRs for me were all the tendons on both legs and feet, from the knees down and the pain was so massive (I am no stranger to pain either), it was impossible to be aware of anything else for a long time. My legs felt like huge, dead tree trunks but were throbbing and on fire at the same time..so weird and my feet and I couldn't move either. They looked no different from normal. It wasn't till day 14 that I got effective pain relief ie liquid morphine; there was a Bank Holiday and a Dr who didn't really know me and didn't understand the amount of pain I was in..that was the worst 4 days ever.

Anyway, I digress again. On the 3rd day of Levo, I felt weak, breathless and very lightheaded, plus my legs were aching and I began to get cramp every few minutes, in my calves, toes, thighs, hands and even in my side. This was continuous. The 4th day I had the most terrible backache and although I have a bad back anyway, this was a different pain. That night I began to cry and didn't stop for 3 days and nights. I had no idea why I was crying but it was uncontrollable 24/7 and I just couldn't stop.

Every day something new happened and the general pains started to become more specific. I also started getting peripheral neuropathy in my feet, with strange tingling and pricking sensations, plus two numb toes, which still are.

I also had about 3 panic attacks during the next few months; I've never experienced these before.

My concentration went to zilch and I still can't focus well. I can't think of the word I need often and forget what someone has just told me. My brain feels like it's fine to mush really.

I didn't sleep, except for the odd hour in the day for about 3 months but thankfully even though I still am awake all night, I do get a few hours in the early hours or in the day but I'm permanently exhausted. It is true Fatigue that we are experiencing and not just feeling tired, like ether you or Gayle said, there's no feeling of being refreshed after any sleep.

I lost my voice for 3 months and the ENT Specialist said that my vocal chords were very dry. I had disastrous consultations with him because he thought I was mad for thinking it was due to the FQs, though it was. They dry out all mucus membranes. Eventually, the hoarseness went and I got my voice back but I had been scared that it would never return.

I was photosensitive and still am; I couldn't bear the light at all and often the iPad screen is too bright and I have it turned low anyway. When I last had my eyes tested 18 months ago, the optometrist asked me if I squinted a lot in the light, because my eyelids have suddenly drooped and now cover part of my pupil. This is also due to FQs, with squinting but also losing muscle tone. I need surgery to lift them but am too scared, so have done nothing yet.

My body thermostat has broken and I was choked to the bone for the first 6 months. All through the hot summer of 2013, I had the heating on and hot water bottles. Now I am still often very cold but can suddenly become really hot (not menapausal flushes) and permanently feel I'm running a low level fever.

I didn't mean to write all this but I suppose that I've tended to dwell on the more musculoskeletal ways in which I was affected, because the pain was so severe I guess and all consuming and it's only in the last year that I've been more aware of my other ADRs.

I wish I could give you an answer and tell you what to do to help yourself recover and I'm frustrated that I can't. A good healthy diet, with lots of fruit and Veg. Some people go completely organic and avoid meat (it contains hormones and possible Quinolones). You could cut out Gluten. Take Multivitamins, especially Vitamin C....I seem to remember reading early on that it can block the FQ from settling in the GABA receptors. There is strong evidence to show the FQs have a detrimental effect on our Mitochondria and FQs cross the blood-brain barrier. Vitamin D might help the Fatigue. In fact I would ask your GP to test you for mineral and vitamin deficiencies.

You will find articles on Floxie Hope, with explanations about the chemo type reaction of an FQ and also some suggestions of things you might be able to try. Avoid anything with Fluoride if you can, as it's the Fluorine molecules in FQs that allow them to penetrate so deeply at a cellular level.

I apologise for yet another lengthy post and for rambling all over the place.

Look up Glutathione...again you will find info on this on Floxie Hope. I really can't recommend too strongly that you get onto that site and begin to read. Lisa has organised it well and you can see a menu of her various pieces of research and writings, quite clearly. There are personal stories of people who've recovered. Lisa was Floxed herself.

I need to shut up and look for that letter...probably be tomorrow now though, unless I get lucky.

Carol