Last week my consultant stopped the Methotrexate I was taking. I was on 25mg a week every Thursday. I have not taken any for about 11 days now. I am in more pain than usual today and I would like to know if the drug comes out of your system that fast or am I just having a bad pain day?
Hi SharonAnne, I had to stop taking mine recently and I had missed 2 doses when my problem falred up again. By the time I had missed 3 doses, I had had enough! I am back on it, I am only on 10mgs/week
Thank you 
that's helpful to know. I hope you are feeling better.
Why did he stop it ? Did he replace it with a different med ?
I had to stop taking methotrexate in May this year as I had a chest infection and was on antibiotics. I had forgotten what the pain was like without methotrexate but
soon found out after about 10 days without it. The pain was awful so I started back on the methotrexate about a week before I should have done. I was on 10 mg tablet form. They then put me on weekly injections which meant I missed some of the stomach/vomiting/nausea side affects.. They then put me on 15 mg and I have less pain with the higher dose. They are now organising for me to self inject which will be much better as I have to take time off from work every Friday morning to go to the hospital for the injection. I havE ANCA vasculitus, an auto immune disease that is quite rare where the body attacks the blood vessels.very painful. Sometimes affects my lungs. What were you put on instead of methotrxate? Hope your symptoms have settled. I would be interested to hear an update from you on this forum. Kind regards. Ladyfox51.
Ive been taking methotrexate for about 2 years now, injection form 20mgs. Ive had infections regularly and had to come off them. I hurt pretty much within 2 weeks and usually ask for a depo injection which is like a miracle until the methotrexate gets back in your system.
You don't say why you had to come off it...when the rash that I get with methotrexate gets too bad I take a reduced amount but as Mrs Mop has said, two weeks without it and you can usually feel everything start to sieze up! I forgot to pack my pills & had 3 weeks on holiday in the sun...no pain...but first day back in the UK & wham! Crippled. I'm still wondering whether the heat helped because I've had a pain-free summer this year.
Ditto re holiday in the sun. I believe it really does help, I havent been as bad this year
I hope that they will get you sorted out asap & the Mtx injections help. I self inject my 20mg Mtx weekly and mostly have few side effects. Mtx has now mostly changed to a pen format ( similar to the kind for diabetes). I used it for the first time on Sunday. A bit fiddly at first but should be easier in future. Im sure you'll find it ok with some guidance. Sorry about your other condition, RA is bad enough.
Personnely I think we don't realise what pain we have been putting up with. Then we stop the meds it hits us. Sounds like an addiction I guess but I am on mtx and have only been on it a month. Already being told to take half of the dose after being sick. But oh my, The cortesone injections.........long may they reign. I do hope you find your meds niche soon. Best wishes xx
I go away to the sun every year, I can breathe better and find I can walk forever. The only sympton I get is the feeling of sausage like fingers, but am willing to keep trying things if that is all I have to put up with. Best to ya!
Dear SharonAnneH,
I had to stop taking it a few weeks ago because of a liver problem. I am now in agony - barely able to dress myself, getting very little sleep and in constant severe pain.I'm going for a blood test tomorow and can't wait to start taking it again!.
Fussybag, spoke to soon, just got back from hot climate, sun didn't seem to work this time. Had to stop due to recurrent infections so not had methotrexate for at least 2 months. Back on it now watch this space although still hurting. Same to you
Fingers crossed they get you sorted. Been there with the liver problem, not nice. Ive been using Votarol gel rub which does give me some respite, try it, it might work for you
Hi everyone,I'm new to this page and was very interested in this discussion I have been on Methotrexate for four years and was recently taken off a month ago due to my liver function tests not being so good! I am in terrible pain and am really concerned that I'll go back to where I was and a quite nervous,any advice greatly appreciated
I found your question interesting. I don't know the answer but when I've had to come off MTX (for the same reason) I have managed a fortnight before my RA pain kicks in and a month before I feel that I'm back to square one. For all its side effects I've found Methotrexate to be a wonder drug - giving me my life back. Good luck with everything.
Hi everyone,I'm new to this page and was very interested in this discussion I have been on Methotrexate for four years and was recently taken off a month ago due to my liver function tests not being so good! I am in terrible pain and am really concerned that I'll go back to where I was and a quite nervous,any advice greatly appreciated I can relate to what you are saying SharonAnnH
i am leslie and new to this and i use to take 8 tabs a week i stopped taking a couple weeks ago and i am in agony but will not back on them because i thought they was not working and yes they do come out of your body quiet quickly
I am not certain when this was originally posted Leslie but I had to stop taking the MTX altogether because of the pains it was causing in my joints. It also caused a totally addled brain!
I forget when I actually stopped it but I have been taking Mycophenolate Mofetil since about April of 2015. It is a much pleasanter drug to take but of course, it too has its own side effects. I have had to drop the dose because of side effects but am still taking it at the moment.
I have an auto immune skin disease called Mucous Membrane Pemphigoid.
abòut five minites never good at spelling have ra for about 20years then they started me on metatrexate i thought it was not doing anything after 4 months so came of now in agony but not going back on it