Huntington's disease (HD) is an autosomal-dominant, progressive neurodegenerative disorder with a distinct phenotype, including chorea and dystonia, inco-ordination, cognitive decline and behavioural difficulties. Huntington's disease is associated with cell loss within the basal ganglia and cortex. Huntington's disease was first described by George Huntington in 1872. Huntington's disease is associated with increases in the length of a cysteine-adenosine-guanine (CAG) triplet repeat present in a gene called 'huntingtin' (HTT) located on chromosome 4p16.3.1 There are many symptomatic Huntington's diseasetreatments but no as yet, there are no therapies that alter disease progression.
This is a companion discussion topic for the original article at https://patient.info/doctor/mental-health/huntingtons-disease-pro