Hypogammaglobulinaemias are heterogeneous diseases of either primary origin (genetic disorders and/or chromosome anomalies) or secondary origin (induced by extrinsic factors - infectious agents, mediators such as corticosteroids and immunosuppressants, chemotherapy, metabolic diseases such as nephrotic syndrome, nutritional disorders, and environmental conditions such as ionising radiation).1
This is a companion discussion topic for the original article at https://patient.info/doctor/haematology/hypogammaglobulinaemia