Is it safe to take certain recreational drugs on levothyroxine?

does anyone have any experience of taking recreational drugs whilst on prescribed levothyroxine?
i know that ketamine reacts with levothyroxine -raising the heart rate and blood pressure. but all the information i can find and all the research that has been done is about the affects of levothyroxine with ketamine as an aesthetic that is injected (so therefor in a large amount at once)
however, there is no information about the results/risk of levothyroxine with smaller non injected amounts of ketamine done recreationally.
is it lethal and should drug users know about this?

I think you may have better luck with this on reddit.