Langerhans' cell histiocytosis (LCH) is one of the 'histiocytosis disorders', as defined by the Histiocyte Society. Langerhans' cell histiocytosis is caused by clonal expansion of myeloid precursors that differentiate into CD1a+/CD207+ cells in lesions that leads to a spectrum of organ involvement and dysfunction. The pathogenic cells are defined by constitutive activation of the MAPK signalling pathway.2
This is a companion discussion topic for the original article at https://patient.info/doctor/multisystem-diseases/langerhans-cell-histiocytosis