The syndrome was first described by Marchiafava and Bignami (two Italian pathologists) in 1903. Marchiafava-Bignami syndrome is a rare neurological disease characterised by necrosis and demyelination in the fibre tracts of the corpus callosum. It is commonly linked to prolonged, severe alcohol intake and malnutrition. It is most frequently seen in middle-aged or elderly alcoholic males.1
This is a companion discussion topic for the original article at https://patient.info/doctor/mental-health/marchiafava-bignami-syndrome