Multiple endocrine neoplasia type 2 (MEN2) is a rare familial cancer syndrome caused by mutations in the RET proto-oncogene. The underlying problem for all the MEN syndromes is failure of a tumour suppressor gene. The genetic defect in MEN2 is on chromosome 10 (10q11.2) and has also been identified both for MEN2A and MEN2B.1 2 The prevalence of MEN2 is about 1 in 35,000.3
This is a companion discussion topic for the original article at https://patient.info/doctor/endocrine-disorders/multiple-endocrine-neoplasia-type-2-men2