Dear everyone,
While on MTX in 2014/2015, I had to take antibiotics at some point (actually 3 times). Back then, I remember I experienced increased joint pain and stiffness during the treatment that would resume 1 week after stopping. Has anyone experienced something similar or have an explanation for this adverse reaction ?
Hi.... Yes I've had this happen too. My doctor said the antibiotics intevere with methotrexate..
Antibiotics DO interfere with methotrexate - they reduce the amount the kidneys excrete and so the blood level usually increases. Which you'd think might make it work more. Normally you are told to stop taking mtx while taking abx - and obviously stopping mtx will potentially lead to a flare of symptoms.
Ok, how interesting ! I really experienced something spectacular back then, it was as if my whole body was going stiff but not only in the morning, the whole day through.
Thx for your reply EileenH,
Every time when I stopped MTX, the injection was recent and this stiffness came really fast, after a couple of days, like my whole body was going into a painful stiffness. And I have been wondering why was that and if it was only me.
When I stopped MTX altogether, I did'nt experience that same reaction. Actually, I had more something like a complete relief. It did'nt last very long of course, but it was something completely different.
It's strange isn't it - do update if you ever find out what caused it!
I will I'm so curious, can't help it I guess.
Have'nt found anybody to discuss this before and yes, I think it's quite strange.
Can you explain what exactly happened to you ?