Hi Ricky,
Yes, ven will impact your health negatively over time. I have the female equivalent of ED and have had for the entire 20 years of being on ADs. Just search around the web and you will find tons of people with this problem. I have heard that 80% of SSRI/SNRI takers have sexual side effects.
Ven is also one of the hardest to get off of, with horrific protracted WD if you come off too quickly. There often will be a honeymoon period where you feel fantastic for the first two months off, but then the wheels come off the bus and this can go on for months and even years for some.
The doctors won't acknowledge this. Search for Complex Withdrawal Model by David Healy to read a nice synopsis.
Doctors have us come off way too steep and too fast. 10% of the previous dose per month is the recommended taper schedule and even that doesn't guarantee the wheels won't come off the bus months out.
Since you are doing well with your depression and are taking the extended release version, you could do the bead-counting method. I'm assuming yours has the little beads inside the capsule. Open three or more capsules and count how many beads each has. Hopefully they are pretty close to the same, though I've read that the manufacturer is allowed as much as +/- 10%! Once you know the average number, you can start removing 10% of the beads each month. Journal your symptoms so that you can see if you have any mild WD symptoms and how many days from the cut they occur, and how long they last. This will allow you to determine how often you can cut. You want to stabilize well after the symptoms, and never cut when you are still having any, as this will only cause more instability.
This should go well until you get down to 37.5 mg, which is the minimum effective dose. At that point, your serotonin receptors are still 80% occupied (the top occupancy with higher doses only being about 90%). Once you start cutting into that 80%, the likelihood of WD symptoms increases, so if you have cheated and reduced by more up to this point, you better slow down to 10%! Occupancy drops precipitously with small dosage drops at this point.
Since the brain has remodelled in response to the drug's action, taking away drug causes imbalance of neurotransmitters, and until the brain adapts and remodels to these changes, WD symptoms can occur. The goal is to make cuts so small that the brain hardly notices, is able to adapt without too much imbalance, and WD symptoms remain tolerable so you are funcitonal.
Meanwhile, I would have a visit with your doctor to check out your heart funciton. I do know of someone on another AD that had to come off because of heart arrhythmia. He is suffering bad WD because he HAD to come off, no two choices.
I will add that withdrawal includes symptoms that appear like the original depression but aren't, yet doctors will say you have relapsed and throw you back on meds. Reinstatement can help alleviate withdrawal symptoms, which is what is really happening, but often people will be thrown on new drugs (which can't cover up WD from the one you came off), including benzos and anti-psychotics because their WD makes them appear bi-polar! It can get ugly fast!
I hope this helps, Ricky. More than you probably wanted to know.