Waking up with itchy hands/rash.

For the past 2 mornings I’ve been waking up and everything is normal, but about 10 minutes after waking up my hands begin to itch. Redness between fingers, and low raised hives begin to appear on my hands and wrists. I take Benadryl immediately and it goes away. 

You are allergic to something. Have you changed your hand lotion or washing powder? Sometimes hives just happen and will burn themselves out over time.