Why would a woman’s estradiol levels be high (600s) while taking the pill? (Should be LOW)? Estradiol reference range is 15-350, high range is during ovulation. A woman doesn’t ovulate while taking the pill. The ovaries should be suppressed and producing a minimal amount of estrogen. (The synthetic form wouldn’t show on an estradiol test as they aren’t bio identical.) Other notable levels are SHBG was 276, reference range is 24-122, elevated D3 (53), borderline low serum ferritin (11), and 17-hydroxyprogesterone was 161 (should be under 80) what could cause excess estrogen and other levels? patient has had one naturally induced menstrual period in the last 9 months. is also complaining of abdominal pain, bloating, frequent urination, and chronically pruned fingertips.