Atorvastatin works in the liver to lower cholesterol, while isosorbide mononitrate works by relaxing blood vessels to improve blood flow. They are processed by different pathways in the body and do not interfere with each other's effectiveness or safety.
This is a companion discussion topic for the original article at https://patient.info/medication-interactions/atorvastatin-and-isosorbide-mononitrate-carmil-monomil-interaction