Je prends actuellement 2X37,5 mg (un le matin, un le soir) et je vais bientôt passer à la formule à libération prolongée, avec la même dose quotidienne. Est-il préférable de prendre les 75 mg en une seule fois (c'est-à-dire le matin), ou d'en prendre un le matin et un le soir.
Merci !
Je n'ai jamais eu cette option. J'ai toujours pris 75 mg vers 20h30. C'était un moment où je savais que je pourrais être cohérent, car je ne me levais pas à la même heure chaque matin.
I would like to point out that taking 37.5 mg in the morning and in the evening equals 37.5mg not 75mg. This is due to the drug's half-life...which is why you take it in two doses - to maintain more consistent levels...of 37.5 throughout the day. Moving to 75 extended release will mean you are doubling up the dose as well as changing release...
Was this advised by an actual psychiatrist or a GP? If latter ask them to first up your dose by adding one more pill of 37.5 to your morning dose for a week or so BEFORE switching to 75mg extended release so you can ease yourself into the 75mg therapeutic dose with a shorter half-life first.
This is how my neuropsychiatrist proceeded and how most people I know are switched from immediate to extended release. Doing it the way you plan to may be a little bit of a shock to the system if you are sensitive.
If you were simply moving from 37.5 extended release to 75 mg extended release this would be less of a concern.
To answer your specific query - extended release capsules are taken ONCE per day and this should be done in the morning or no later than lunchtime. Otherwise they can mess with the quality of your sleep.
Kathi, merci beaucoup !
Purpledob, merci beaucoup pour cette excellente réponse ! Je consulte un médecin généraliste, et il m'a recommandé d'essayer de réduire ma dose de Ven de 150 mg/jour à 75 mg/jour, et espérons-le, en dessous de cela à l'avenir. J'ai réduit de 150 mg à 112,5 mg au cours des derniers mois en utilisant des comprimés à libération standard avec quelques difficultés, mais cela va.
Maintenant, je veux essayer 75 mg/jour, et j'ai vu à plusieurs reprises sur ce forum que les gélules à libération prolongée sont plus efficaces. (n'est-ce pas ?). Il m'a prescrit des gélules à libération prolongée de 37,5 mg afin que j'aie la flexibilité de réduire progressivement si je peux. Mes questions pour l'instant sont : (1) dois-je prendre deux gélules de 37,5 mg en même temps, et (2) si oui, quelle est la meilleure heure pour les prendre ?
J'espère que cela a du sens !
Merci d'avoir écouté !!
Hi
ah so you are reducing. Then it is less of a concern. Extended release keeps steadier levels throughout the day which for you, practically, means fewer ups and downs and less tension.
Since you have ER caps at 37.5 you would need to take them at the same time in the morning or latest at noon.
There is a great way of reducing by combining ER with IR release but that may not be necessary at this point since you already did the hard work on IR alone
Take your time when you go on 75 and wait for a couple of months AFTER any adjustment disturbances subside before attempting the next cut to one 37.5 ER.
Good luck
BTW If you were last on 112.5 Immediate Release and taking one 75 IR morning and one in the evening - you are already on 75mg NOT 112.5.
Then by taking 2x 37.5 in the morning you are going through consolidation of 75mg and after 2-3 months dropping to 37.5 should be good. Reduces your chances for a relapse after stopping as well. It is worth it. Basically the longer you take between dose changes the better. I took between 3-9 months between each drop. From 150. No issues, no relapse 4 years - clean.
Wish the same for you.
Purpledob, je suis tellement reconnaissant pour ces réponses très instructives, et en particulier pour vos mots d'encouragement sur la possibilité d'atteindre une cessation totale. J'ai vraiment hâte de commencer ce prochain chapitre.
Merci beaucoup ! 😊😊😊
Purpledob, j'espère ne pas trop m'étendre sur les détails de ma posologie, mais voici le profil de mon passé récent :
15 août 16 - 14 juillet 17 : 1x150ER cap (crise de panique significative début août)
15 juillet 17 - 20 juillet 17 : 2x56,25mg comprimé IR (matin/soir) *
21 juillet 17 - 30 sept 17 : 2x37,5mg comprimé IR (matin/soir) * (j'ai essayé de réduire)
1 oct - actuel : 2x56,25mg comprimé IR (matin/soir) *
* j'ai utilisé un "coup de pilule" pour obtenir les dosages listés !
Si je comprends bien ce que vous dites, mes "dosages efficaces" à partir de juillet ont été la MOITIÉ de ce que je pensais. Si c'est le cas, ce sont de bonnes nouvelles, car j'ai réussi à m'en sortir, bien que pas génial !
Je dois maintenant décider si je vais prendre un ou deux 37,5 ER caps chaque matin.
Merci beaucoup de m'avoir écouté.
Salutations
Yes your dose is considered lower than you thought. Not exactly half but not far from it either due to the rebalancing and recoiling that the brain goes through when treated with IR...especially for anxiety disorder.
Ah...word of warning - You were on therapeutic dose of 150 ER less than one full year. 2 is minimum...4 is much better. (2 for therapy and 2 for maintenance).
You were then switched to immediate release (Only a GP could muck this up like that...) and dropped to 56.25 IR x 2 ...erm...technically close to half initial dose and with a nice spike-dip-spike-dip pattern that IR offers. Not great. FOR ONLY 5 DAYS before rushing down to 37.5 x 2 IR. Of course you are not feeling great LOL. Two.Take two 37.5 ER and stick on them for at least 3 months and I would suggest longer to help your brain recalibrate and pick a good equilibrium to work from moving forward. Do not make the next cut in case of any major life changes, illness or extra stress. Pick a good time for your next cut. Take 2 not one. You may be shooting yourself in the foot otherwise. You are already compromised by that reckless drop. Feel free to consult a psychiatrist for a second opinion if you are unsure. But not a GP.
What should have been done, if IR was to be used as a transition, was to take you down to 112.5 ER for a few months and then introduce 75 ER Plus 37.5 IR (taken together or a few hours apart) to train the brain to dip after 6 hours (IR is fast acting). That way you would gradually adjust to the dip before moving to 75 ER which should be kept for a few months. Then the same as above applied by using 1 x 37.5 ER plus 37.5 IR to retrace the dipping procedure for the brain. Then down to 37.5 ER for a few months and finally down to two 37.5 IR if necessary to further slow down. I was fine without that last step. But then I was treated for 4 years PLUS 2 years maintenance and took 2 years to wean off as described.
I went off twice prior to this and each premature and speedier drop landed me back with a vengeance a few months later. So the final lap of therapy was slow and very carefully designed by my amazing neuropsychiatrist. I was treated for massive GAD. The second relapse triggered transient psychotic episodes...So I was in no rush in the final lap. Slow does it.
Let us know how it goes whatever you decide.
All the best
Je n'ai pas les mots pour vous dire à quel point j'apprécie ces conseils rassurants et pleins de sagesse !
J'ai décidé de moi-même d'essayer la réduction sur 4 jours. Pure ignorance de ma part. Mon médecin généraliste est un bon médecin, mais il m'a essentiellement conseillé de réduire de 150 mg/jour à 75 mg/jour sans guidance spécifique sur les délais, etc.
Avec le recul, j'aurais probablement dû demander une référence à un expert du sujet.
Je me sens très à l'aise avec vos recommandations pour la suite. Je tiens des registres très détaillés de mes niveaux d'anxiété et de la qualité de mon sommeil, et je serai intéressé de voir comment la transition vers les gélules à libération prolongée se déroulera.
C'est incroyable pour moi de voir à quel point c'est rassurant d'avoir une personne compétente qui me surveille. J'ai l'impression d'avoir une longueur d'avance sur la phase suivante 😊
Si vous le permettez, je vous enverrai un rapport d'état plus tard.
Salutations
Hi I'm back again.
I've been talking one bead from my 150mg out for one month and I wake up feeling awful. I've started with two beads less now in 2nd MTH but starting already to lose faith. Don't know if it's already part of withdrawal or what. As I said before I've tried many times to come off with help of dr's was fine for few mths then crashed. So trying on my own. Reasons for wanting are been on it for many years don't feel it's helpful and only recently realize that it must be this medication that's caused my weight gain.
In an awful state!
Can anyone help? Please!
Hi. Would you like to list your history on this drug in some detail?
When did you start?
What symptoms caused you to be prescribed this?
When was the last time you tried to properly come off with doctor's help and how was the taper designed?
How soon after removing just one bead did your condition start to worsen in your opinion?
Were you ever well on this drug?
Were higher doses ever attempted?
Were you ever on any other psychotropic drugs before or after starting venlafaxine?
Any details will help.
See, the problem is, that if you are tapering before actually being well on the drug, you are not likely to fare well however slowly you withdraw. The brain has nothing to draw on or reference to function optimally. Apprehension about impending crash makes you immediately stressed so you end up nowhere.
Have the doctors not suggested a bridge, such as Prozac, to aid in the taper? Have they not advised trying a different dosage? A different drug or combo?
x
I've come down from 150mg daily to 37.5mg per day, after 2 year's use. The effects the past few weeks have been horrendous, suicidal, anger, frustration, depression, anxiety, tearful, dizzy spells. I hate this medication have been trying for several months to get off this nasty drug. Got down to 16mg but the effects were so bad had to go up again, now waiting to see a Psychiatrist for help to get off them for good
Hi my doc wants me to change from 37.5mg immediate release at night to 75mg extended release at nite is there any side effects
Hi did u have any side effects?