more info continued ... Estriol ( Ovestin) ( Ovestinon) vaginal Cream internal and external use 0.1% 1mg ....
Estriol Ovulo 0.5mg vaginal ovules x 20 ( Ovestin)
Estriol – The Power of Weak
Estriol is the third form of estrogen. It is called weak estrogen by the medical profession because it only has 1/25th the proliferative effect on female tissues. At the same time it is called weak, its usefulness is summarily dismissed by American doctors as some unknown and unproven substance – a testament to a profession’s lack of comprehension for anything that hasn’t been spoon fed to them by the pharmaceutical industry.
Your ovaries (assuming you still have them) produce 2 mgs of estriol per day, far more than any other form of estrogen. Estriol levels do not rise and fall with your menstrual cycle19, and their production is not naturally curtailed at the time of menopause.
Unlike estradiol, higher blood levels of estriol are generally protective against breast cancer. One large trial20 showed that estriol did not increase the risk for breast cancer, whereas estradiol did.
In women age 85 and older who have no heart disease, higher circulating levels of estriol21 are present and associated with healthy blood flow and good circulation. An animal study confirms that estriol increases the friendly form of nitric oxide22, an important relaxation factor for healthy circulation that helped prevent the formation of atherosclerosis in this study.
A study of women over 80 taking 2 mg of estriol per day found that it increased their bone density23.
Estradiol drugs are known to increase total cholesterol. A 2-year study of women entering menopause24 found that estriol prevented the estradiol-induced rise in cholesterol. Whereas triglyceride levels also increased in the estradiol drug group, estriol again prevented this result – even lowering triglycerides. Since an elevation in triglycerides is a key sign of insulin resistance, leptin resistance, cancer risk, and heart disease – one can only say that a natural substance that directly guards against this (estriol) is a powerful health-promoting compound.
Estriol is sometimes referred to as the pregnancy estrogen, as its production rises from 2 mgs per day to 8 mgs per day during pregnancy. It is believed that this elevation in estriol is highly protective to the evolving fetus, especially to the fetus’s nervous system25. It is also believed that the rise in estriol helps stabilize the mother’s immune response26 to the fetus, dampening the possibility of the mother’s own immune system trying to reject the fetus as foreign. It has been shown that a lack of estriol is associated with low birth weight babies27. Low estriol is also a factor associated with postpartum depression28.
Unlike the obvious issue of excess estradiol being linked to serious autoimmune problems, estriol is linked to immune stability.
Indeed, the observation of the regression of autoimmune multiple sclerosis during pregnancy has led to some fascinating studies. Non-pregnant women with MS29 have been given 8 mgs of estriol per day (the pregnancy level) and their MS has gone into regression. When the estriol is stopped it comes back, and when it is started again it goes away (including the removal of brain lesions). Phase II clinical trials30 are currently under way. One of the fascinating aspects of these initial studies showed that estriol could powerfully modulate TNFa31, a significant inflammatory signal that is overactive in many autoimmune problems. A separate cell study shows that estriol3216 is far better than estradiol at protecting brain cells from toxic exposure.
Estriol has proven effective as a treatment for vaginal dryness and atrophy33, as well as urinary tract infections. It has been shown to help relieve hot flashes34, acting as a natural hormone balancer. It helps many women with mood. If you try some, make sure you can tell it is doing something useful.
The body of evidence shows that estriol is safe and effective, a form of estrogen that is produced throughout one’s life. It acts as an antioxidant and anti-inflammatory, and is particularly effective at protecting the female system and nervous system.
As with any bioidentical hormone replacement, women should always ensure they are working on an overall health improvement program and it is moving in the right direction. Never rely on any one hormone as a “magic bullet.” And always keep it to a level that is within what your body would naturally produce.
Estriol is readily available in OTC creams and through a compounding pharmacist.
wrinkles yes wrinkles the transdermal cream i get i use .5 vaginally and the other .5 on my wrinkle and leftover i dot a little on my neck under the chin too 
)) comes from a good source do not tell ur doc u want it for that though lo