After my husband had chemo and radium treatment for Hodgkin's Lymphoma, he went into a black hole and no antidepressants would help. In fact, they gave him bad reactions.
Finally his gp thought of Vit B12 and after the 2nd weekly injection he came home humming and said hello to the neighbour whom he had ignored for a couple of years. Even though I had been giving him Vit B12 in tablet form, It seems he was unable to absorb it in that form. It had to be in enzyme form via injections. After weeks of injections, he has finally moved on to a maintenance schedule of every 3 weeks and is so different to his earlier self. Gets into his shed and does things, as well as around the yard, etc. So have your Vit B12 checked out, as well as your Vit D - these are important.
My Vit D consistently stayed low despite tripling my tablet dose. My gp finally said try the Vit D3 drops. My blood tests indicated a rise immediately. 4 drops a day I take.
I have always used oestrogen (only the oestradiol type - transdermal, not tablets) for 26 years. My skin is excellent compared to friends who refused to use oestrogen or did not feel the need for it. I am sure your skin will improve with oestrogen. Also ask dr for script for "Retrieve" cream and use a light smear nightly. Stay out of the sun during the day.
Retrieve is a retina A - the real one, not the weak one in expensive cosmetic creams. That is why you need a script. It will make your skin slough off the old skin and renew itself. That sloughing is invisible (well it was for me anyway), and I also help it by exfoliating with some bi-carb soda powder mixed with some Cetaphil cleanser before applying the cream. As bi-carb soda is alkaline, you must replace the acid mantle on your skin with some cheap white vinegar sprinkled in a wet face washer. All these products are cheap, except for the Retrieve but it is still a lot cheaper than cosmetic creams, who claim to achieve the same.
Go gently. If you skin is very dry, try extra virgin coconut oil - the good stuff that you can eat. Consume it too of course, put it in your hair for at least half an hour before washing it. As I tend to have an oily scalp, I make sure that I just smear it on my hair and comb through. I do not use conditioner.
Take your progesteron as a separate tablet, not combined with oestrogen.
I am sure this will make a big difference to you.