Pregabalin Withdrawal Timescale and Symptoms

I have been on 600mg Pregabalin for 2 years for muscle spasms in the back as a result of the muscles in the left lumbar region apparently distrophying.  

I have been warned about hyperalgesia syndrome and have been trying to self withdraw from the drug.  300mg per day to start with and achieved with fairly severe side effects but were alleviated within three weeks.  And now I have gone cold turkey for two of the most physically horrible weeks possible - intense pain, nausia, lethargy and foggyness, sickness and depression.  

Im sticking at it as it has to be worth it - has anyone else done similar with same quantities?

Hope you're feeling better by now...wasn't your weaning off a bit drastic? My doctor has said to wean of 25MG a day.   My best to you...

Hello Paula, I only wish I could have got off the pregabalin myself earlier so I could have answered your question in better time. I hope you managed to get off the drug and are feeling much better for it.

I was taking the full dose of this awful drug for years, along with naproxen and tramadol. Years passed, doctors seemed happy to keep on prescribing and only pharmacists questioned me being on so much.  This was when I questioned it too.

I have disc bulges in my neck, one impinges on the C7 nerve root, this is the cause of a lot of pain, muscle spasms and numbness. Consultants say it isn't an emergency situation, therefore they do not offer surgery. Whether I want surgery is another story.

Anyway, I thought it was time to try and go drug free to make sure I knew how much pain I was really in and whether the meds were as necessary as I thought they were, and indeed doctors thought they were.

I had many side effects with pregabalin, including dizziness, drowsiness, being off-balanced, blurred vision, leg swelling, finger swelling, and most irritating of all not being able to form proper sentences.

So on a whim I started my yoga again, bought lots of vitamin supplements, changed my diet, cut out caffeine and went cold turkey off the lot!

It was weird, so much more pain at first than I expected, I felt close to giving up, but I am strong so stuck with it. I questioned whether I was in pain because the drugs were wearing off and they perhaps were making life more bearable. And now I wasn't taking anything my life was going to be unbearable....but that was not true.

It got better, but after quite a few weeks. I went through severe itching, pain all over, foggy headed, confused (although the pills did that anyway), I felt detached, and I felt very low.

After a few weeks on my new healthy lifestyle I started to notice a difference, the pain wasn't as bad as it was before I started all the pills, and I feel more positive, I think more clearly. My eye sight seems better, my thoughts are more positive, and although I still have pain, I find I can tolerate it more now…who would have thought?

I even think that due to my stress levels and anxiety over my sudden deteriorating health a few years back, the pain was worse because of my state of mind. I think I must have been too frightened to stop taking these drugs before, addicted I am not sure. If you get addicted to these drugs, it is more about the anxiety of being in the awful pain again. But I am no expert so couldn't say for sure.

One thing is for sure, after taking pills for a long period of time you need to take a break to see if your condition has in fact improved, I believe after time our bodies can fight pain more effectively without the crutch of pills, of course not for everyone, but a lot of people can find relief through other means. Try yoga, relaxation, massage, walking, laughter therapy, tens machine, heat/ice when pain is bad. But pills become a real problem when we come to rely on them as our bodies are not naturally fighting the pain as they should, we just rely on the pills, until we don't even know if we are in pain because of our condition, or the pills are making us ache all over as a side effect. It is well documented that the human body is amazing and can get over some pretty debilitating conditions, or at least find ways to live with them a little better.

I am not in as much pain, I took a risk going cold turkey, but it paid off. I went through hell, but it made me stronger. Now I am going to try with every ounce of my being to live with this condition, kick it into touch with positive thinking and a healthy fun lifestyle.

I really would advise anyone on this drug to try weaning off it, you never know, you might feel a lot better. Just like with everything in life, give it a little time. Don't panic if you get symptoms, just know it really does get easier. Keep in touch with other people in the same boat, even if it is a few lines on forums like this, with a little support and positive thinking anything is possible.

I wish you and other sufferers of pain all the best of luck with your journey through this wonderful life.

Dear Paula

When i read yours and other peoples experience of coming off this awful drug I was so relieved to hear these were the result of withdrawal because i have been thinking i was seriously ill.  Terrible pain, awful nausea, dizziness and complete loss of appetitie.I really think it is worth staying off. I have heard so many bad reports of this drug including from Doctors and chemists. I am going to write to my Doctor who prescribed it and suggest they look at this site.

I have had some terrible days but they are getting less. I drink plenty of water and exercise and eat sensibly. Dont know if it helps but i feel i am doing something to help myself. i would never under any circumstances take this drug again.

All the best

DerynElizabeth

I know it's a year later, I was on 600mg this time last year, and starting a taper of a starting cut of 5mg a day, as I hadn't been on 600mg long. I was only onn 275-450, taking recreatinally, but when I split the dose into four, it had horrible wds, so i gently nudged it up until I felt bearable, not well, but bearable, and started my taper. As the dose got lower, I had to reduce my cuts, and im on 3mg 0.8mg cuts, off in a few days, the physical withdrawals went very soon after I started daily cuts, but the  mental emotional side of it is terrible, and I had multiple drug addictions and drink issues but I gave all up barring valium which I am titrating downwards daily, nice and smooth until I slide off at 0mg with daily cuts.

Hi Paula. Hope you can help me out with my situation. I'm 22 years old guy. On 3rd March 2017, I smoked hash with my friends and my blood pressure rose 190/100 mm of Hg and my condition was so severe that I even told my parents I'm about to die. These might be my last words you are hearing on phone. After 2-3 days of hospitalization, I got home. But since then I experienced different allergic reactions, muscle stiffness, high blood pressure, tingling numbness in genitals, severe pain in my right temple area, high palpitations, anxiety, insomnia, very SEVERE PRESSURE BEHING MY NOSE,FOREHEAD, CHEEKS. I started taking Pregabalin 150 mg per day along with Inderal 40 mg , Citanew 10 mg & Rivotril 2 mg on 8th of April 2017. I felt better now that I weaned off the whole medication properly and stopped taking it on 1st August. My conditon for first week was better. But now again I feel like my condition is same like before from where it started on 3rd March. Severe pressure behind my nose bridge, eyes, forehead & cheeks. Allergic acne on chest and back, itchiness, muscle stiffness (severe not able to cope with daily life), insomnia, wet dreams on daily basis, dizziness and much more. I'm just losing hope and want to suicide. I'm in my senior year of Engineering Course. I don't even want to go to university because I can't tolerate my pain and it stops me from my daily life routine. PLEASE anybody help me get out of this. I would be very grateful to him/her for the rest of my life. Your one kind opinion can save my life. 

Hi shahroz 98724

We note from a recent post which you have made to our forum that you may be experiencing thoughts around self-harm. If we have misinterpreted your comments then we apologies for contacting you directly. But if you are having such thoughts then please note that you are not alone in this, and there are people out there that can help.

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Their contact details are on our patient information leaflet here: https://patient.info/health/dealing-with-suicidal-thoughts, which also offers lots of other advice on how you can access the help you may need.

If you are having such thoughts then please do reach out to the team at the Samaritans (or the other people detailed in our leaflet) who will understand what you're going through and will be able to help.

Kindest regards

Patient

Hi, not with the same quantities,I have been on lyrica for about 9months. I was very reluctant to even try it (my dose is 25mg per night). Yes it does help with the pain even on that low dose,but whilst I have a good nights sleep,the following day it takes me a while to come to, I mean that I seem to have to get myself together,but during the daytime I have feelings of fatigue and wanting to sleep,and same in evening.Feeling Lethargic also. 

This becomes rather embarrassing also so I decided that I would like to come off of this medication. and have been told whilst waiting to see my Rhuemi who put me on this medication to take the medication every other night instead of every night. I have to wait at least 4-6 weeks before my next app with Rheumi

I have recently had shingles, and did not experience any pain whilst on regular Pregabalin, but pain has increased since reduction. I am also on reduction of Steroids

 

Hi Sally,

I found your advice very helpful thank you. I have also withdrawn from Pregabalin 600mg over a significant period of time, down to 100mg which I decided to stop over Xmas. I am also suffering many of the side effects you described (and more) and was wondering what supplements you took to help you?

Many thanks

Emma

Hello Emma.

Firstly well done with you battle with this medication .

I will quickly run thru what i came off and what i have done to put things right after having my personality stripped by drugs.

425ml pregab

40ml Martizapine

100 Quertapine

8 .30/500 co.codamol

7.5 zimmervane.

All the above per day for 4years.

I am an all or nothing person with a additive personality Bipolar basically.So i am in no way saying that stopping dead with medication is a good sensible idea i say this before the screams and rants flood in from other patients .The point i am trying to make is withdrawal is a very personal thing and self absorbing it can become bigger than you and the amount of thought put into whats down to withdrawal and whats down to your illness become blurred. I stopped everything well over 50 days ago and channel my thoughts into reconnecting pathways in my brain and reignited my passion for life.Diet herbs excercise have become my obsession not giving myself anytime time to dwell on how dreadful i feel.

Just the loss of weight has been inspiring enough but on top of that seeing situations clearly for what they are is of great benefit if the darkness starts to creep in.I wont go into all the brain food am having .But something has to be said for flushing your system out as quickly as possible sooner all that nastiness is out my system the better and alot can be done without pharmaceutical intervention (IN MY CASE)

You take good care an there is alot of good to come when your totally off it

Cheers Paul

HIYA SALLY

YOUR ARTICLE ON THE PATIENT FORUM INSPIRED ME. I HAVE BEEN ON 600MG PREGABALIN FOR 4YRS FOR NERVE PAIN IN MY LEGS WITH M.S 20YRS . LAST WEEK I REDUCED IT BY 200MG.AND IT'S BEARABLE.

AIMING TO REDUCE A FUTHER 200MG AFTER 2WKS AND SO ON.

I'M NOW 20STONE AND WORRY FOR USING THE HOIST.

I HAVE AN ENLARGED STOMACH AND INTEND GETTING MONTHLY MASSAGES FOR IT.

THANKS AGAIN, KIM X

DEAR SHAHROZ

I REALLY FEEL FOR YOU AND HOPE YOU HAD SOME HELP TO COME OFF ALOT OF YOUR MEDICATION OR PREGABALIN.. TRY MEDITATION ,MASSAGE AND USE CHILLI RUB [CHEAPEST FROM THE CHILLI PEPPER CO., HOTTER THAN CAPSAICIN]. 

FOCUSING ON YOUR ENGINEERING IS A MUST.

GOOD LUCK, KIM X

My nan has been on 600mg pregablin for over 6 years.

She started showing dementia like behaviour and been back and forth from AnE. The Dr there put the episodes down to the pregablin and horamorph.

The Dr has told her to stop taking pregablin completely as well as cutting the horamorph. She is 1 day in cold turkey and is in a complete state!

I feel so sorry for her she's in her 70s.

DEAR SIAN

I AM SO SORRY TO HEAR OF YOUR NAN, SURELY THE DR. CAN SUGGEST COMING OFF IT GRADUALLY IF IT HELPS, MY DR. ALSO SUGGESTED COLD TURKEY BUT FOR MY SON SUGGESTING GRADUAL WITHDRAWAL.

[LIKE WITH ANTI-DEPRESSANTS  IT HAS A DETRIMENTAL EFFECT IF NOT WEANED, N MY GP DID NOT SEEM KNOW MY HISTORY AND APPEARED RUSHED WITH THE TELEPHONE APPOINTMENT].

THE ONLY SYMPTOMS THIS PAST WEEK OF 200MG LESS OF PREGABALIN IS AN IMPROVEMENT IN MY SPEECH , WHETHER THAT'S DUE TO LESS MEDICATION, I COULDN'T SAY. I COME OFF A FURTHER 200MG ON SUNDAY 10/01/2018, WILL KEEP YOU POSTED.

GOOD LUCK WITH YOUR NAN [HAVE ONLY POSTED SUGGESTIONS, AM NOT A DR.]. KIM X

 

Hi Paula

Are you still off of Pregabalin? I want to get off it too but I’m worried about the withdrawal and I don’t want to consult my GP over this right now. 

FURTHER TO MY LAST POSTING, I MANAGED TO WITHDRAW FROM 600MG OF PREGABALIN, LASTED 2DAYS BUT WAS IN SUCH PAIN THAT I WENT BACK ON 400MG AND MANAGING WITH THAT AND MY CHILLI RUB. ALSO HEARD OF GOTU KOLA. HELPS ALOT OF AILMENTS WITH INFLAMMATION. I TAKE CAPSULES, MY SISTER GROWS THE PLANT FOR SALADS, SEEMS TO WORK.

I had surgery on a herniated disc a month ago today and have been decreasing my lyrica ever since. I went from 450mg to 150mg in about 10days post surgery. BAD IDEA. I was pretty much bed bound with nausea, diarrhea, migraines and argh the itching.

I decreased by 25mg every few days after that. I still get nauseous, anxious and turn into the worst sleeper for every decrease. Now only only 50mg a day. I'm just going to suck it up this week and get off it. 

On the positive, I've lost the 6kg I gained when I was injured. I can think clearly again and that $40 a fortnight now goes in my pocket. 

My advice is recover from surgery before you decrease or decrease slowly. That one week tapering guidance is for crazy people. I thought I had gastro for the first few days.

I can't believe a doctor said that! They can't have read the advice and research. It is dangerous to go cold turkey from a high dose, especially when you've been on it for more than a few weeks. I hope your Nan is OK.

To anyone else, there is a good reason why this drug needs to be tapered off, please follow the proper advice or you might end up in hospital. If you cut down too fast increase back up a little and go back to your doctor.

i just saw this post, my hubby has taken 450mg a day and has for back problems also for four years, no plans of weaning off them but it is in our minds what if he ever has to,. he needs them though to work. How did you get on with it all, i realise it was a few yrs back, How are you doing? Didnt sound easy at allllllllllllllllll

I just started coming down from 500mg. The best advice, based on research, is to come down by 20mg at a time but my GP won't do that so I'm stuck with 50mg decreases. Not sure if they don't want to issue extra prescriptions or if the 20mg one costs a lot more (the pricing structure is odd as some of the larger dose tablets are the cheapest).

I'm really feeling it. I'd tried their advice of alternating days but that did not help at all, if anything I felt worse. So I dropped just down by 50mg.

I have worse insomnia and noticeable tremors (no cooking for me, no sharp knives) and I itch. How I itch.

It has been nearly two weeks so far.

And my short term memory is worse than fibro fog. I'm wafting around casually forgetting everything.

The things that keep me going are that my pain is no worse, I've lost a bit of the weight that had piled on, and the discontinuation symptoms are short-term; they will stop.

My aim is to get settled on 450mg, wait till everything feel at least the same as before then try 400mg.

But if I go lower I really have to nag my GP because under 200 the 50mg decreases apparently feel a lot worse and I'd want the 20mg tablets.