Splenomegaly is an enlarged spleen. The spleen is involved in producing protective humoral antibodies, the production and maturation of B and T cells and plasma cells, and removal of unwanted particulate matter (for example, bacteria); it also acts as a reservoir for blood cells, especially white cells and platelets. When the spleen is palpable it has usually reached at least twice its normal size.
This is a companion discussion topic for the original article at https://patient.info/doctor/splenomegaly-and-hypersplenism