Warfarin and cbd oil

i would like to know if it is possible to take cbd oil for anxiety and depression whilst having been prescribed warfarin

Why do you want to start taking cannabidiol.

It is a CYP Inhibitor - so may reduce warfarin breakdown and increase therapeutic effect (increase your INR).

I wouldn’t do this without talking to the person who manages your INR/warfarin.

 

Thats what i needed to know, thanks.

it was suggested as a help for anxiety and depression (not by doc)

i suppose thats one more door closed for help.

i wonder if i asked to come off warfarin it would make life so much easier.

What are you taking Warfarin for?

Prophylaxis for a p e in 2014 after an op for disc herniation. Never had any more since

Are you under a hospital consultant for it?

Was at the start of anticoagulation but assed to gp to just monitor inr. Never sees his patients again unless another event.

Have you only ever had one PE?

If so you could ask your Gp whether you could come off warfarin.

If you’ve had multiple PEs - you need to stay on it for life.

Alternatively if you have a thrombophilia - again you need to stay on it for life.

 

I have only had one p.e. Four years ago after surgery.

i had a dvt on a plane 12 years ago. Six weeks of clexane then off.

i dont understand why the anticoagulent consult says its because these were unprovoked i need to stay on.

basically, I think they were provoked, one by flight, one by surgery.

its a question of who is right

You’ve had a DVT and a PE - thats why they want you to stay on for life.

Even though they followed provoking events?

I hope you got good answers to your question. If you’re still in doubt ask PCP to refer you to a hematologist.   I had two PEs about two months after a hip replacement, about 45 days apart.

I needed to have a revision done on that hip, so the orthopaedic dr referred me to a hematologist. After her tests were back it was “Yes, not only do you have to stay on it for life, you can’t take any medications that either interfere with the warfarin, such as NSAIDS, you can not ever take estrogen period”.

I’m a retired ER RN. I have degenerative joint and disc disease. I also have kidney damage. Because I take warfarin and the kidney problem I can’t take the only thing that actually helps the pain.....ibuprofen. 

Cbd oil deactivates the enzyme in your liver responsible for metabolizing many drugs, including warfarin.  You could have a high INR and a high chance of internal bleeding.   If I was in your place, and I kinda am, I’d say forget the oral cbd and stay on warfarin.  

Thanks for all that information, yes it looks like we are on this for life and that just makes so much more of a nuisance for other things.  My dentist wanted tomgive me flagyl for infection and its not a good one for warfarin either, much monitoring needed.

i have suffered from chronic anxiety since all this and i wanted to try the oil as they have tried anti deps with me and i just cant tolerate them so left inlimbo.  If it was only warfarin i could cope but this is a problem as natural anti deps not allowed and some others too.  I dont want to takemthem but am told they would help anxiety, well they havent if anything its worse. Dont know who to ask next as tried cbt, hypnosis, mindfulness etc. Changed diet for warfarin and having digestive issues since gallbladder out soma lot in the mix for me.

As a user of warfarin in the past, I am a passionate advocate of the NOACS - Apixaban being the one that I am taking (lifelong).

Although warfarin is a tried and tested anticoagulant (an old friend of mine), far too many dietary and medicine interactions, together with the inconvenience of regular checking of INR, makes it a rather inconvenient method of Anticoagulation. Particularly for those, like me, taking Anticoagulation medication lifelong.

Apixaban certainly does not react to the many food groups that warfarin does and does not require testing other than twice yearly liver function blood tests - mine have been absolutely fine over the past two years.

CBD oil does appear to react with warfarin  - the jury is out with regard to its reaction with Apixaban. Mixed opinions and advice. 

I keep checking the OACs to see if there’s a reversal agent. I did not want to switch over until there was. I see Prodaxa has a reversal agent now. Eliquis probably will have before too long. 

I’m going to check out the reversal agents to make sure they don’t have bad side effects and are compatible with the other damn meds I take. Sheesh. I really hate getting old. 

Thank you so much for the heads up.

I like the OACs because they only interfere with one process in the blood clotting cascade, whereas warfarin interferes with five. 

I’ll let you know what finally works out for me. 

Thanks so much again. 

I have a home INR tester so I test as often as I feel necessary which seems tone every 3-4 days for me as I am vegan and vary my plant based diet. I vary my warfarin or greens as necessary. I can the tester on Amazon and testing strips are about $4 on E-Bay. I report in to a warfarin home testing clinic. I read if you start CBD oil you should test your INR more frequently to see what CBD's  effects are. on it.  It is also recommended you start out with small doses of CBD oil to see how it effects you and increase levels weekly so you have control over the side effects. 

I don't know if your GP or chemist have any experience or can say anything other than do not take it.

Just as a follow-up that these people know what they're talking about.  Having surgery, taken a long flight, these things shouldn't cause a clot and, in the vast majority of people, they don't.  One incidence can be written off, but two points to something bigger.  You really should work with a hematologist to get a full panel of bloodwork and see if there is a proper diagnosis to defend taking warfarin long term.

All that said, I've been on warfarin for over 9 years after one incident--a clot in my jugular--brought to light my condition.  I see two different doctors and they sometimes forget the other one exists.  My hematologist treats my thrombophilia and everything related to it while my PCP treats all my regular old aches and pains--which is why my PCP prescribed me CBD oil for my arthritis.

​She, of course, had no idea that it interacted with warfarin and I, naively, didn't look up any interactions in advance of taking it.

​What happened?  Have you ever accidentally taken too much warfarin?  I took the CBD oil in the morning before breakfast and by lunch time it felt like my blood pressure had plummeted.  My head was spinning, I was shivering, and I felt a little delirious, not to mention nauseous.  I was useless to my family, including my two young'uns, for hours as I worried that I was coming down with something.  My husband pointed out that it was the first day I had taken the oil and finally, when I could sit up long enough, I looked online for interactions.  

​So, no, you may not feel you need to be on warfarin anymore--that's something to work with a hematologist on.  And if you need to be on anticoagulation for life you may want to explore other options, such as xarelto or pradaxa, which aren't as restrictive.  But for right now, I strongly recommend steering clear of CBD oil.  The side effects are unpleasant at the least and incapacitating at worst--I seriously couldn't walk.  I just laid on the floor waiting for the spinning to stop!  My best wishes with all of your health concerns!

Well that certainly has made me understand i cannot use cbdoil so its a no brainer.

i dont know what you mean when you say i need to see haematologist regarding my provoking symptoms.  I saw professor of anticoagulation four years ago and he just said, two events, no sign of factor V leiden therefore warfarin for life. Dont need to see you again. 

I've never heard of a professor of anticoagulation--though I don't doubt that such a thing exists.  What I do know is that, if you're going to be on anticoagulation for the rest of your life, there should be a diagnosis other than just "you clotted twice, so that's it."  I'm guessing the professor did a more complete blood work-up beyond Factor V Leiden, because there are many other thrombophilic factors.  I'm not Factor V Leiden either.  There's also aPL, aCL, SLE, and a whole host of other things that can cause a person to clot.  Find that bloodwork.  Call the professor and ask his/her staff to track down your records.  Have a physical copy sent to you to take to each and every doctor's appointment you go to from here out.  Be your own advocate.

You originally posted because you were looking for a way to treat your anxiety and depression that didn't interact with the warfarin.  This is a question for a hematologist--they deal almost exclusively with blood interactions.  Keep in mind, even if your anxiety is a hindrance in your daily life, your doctor is not going to prioritize it.  They see a history of blood clot and they think, 'if I don't treat this I may have a law suit on my hands.'  Anxiety is not considered life-threatening.  The doctor will always prioritize treating a history of clots over anxiety, if for no other reason than to cover his or her own back.  You have to speak up for yourself and make it known that the anxiety is life-limiting.  But you also need to know your underlying condition when it comes to the clots.  Do not assume that all of the doctors you have seen have access to the same records.  HIPAA requires that they don't without your express written permission.  You have to carry that information with you, either in written documentation or in your head, because it is YOUR life they are fiddling with--your blood and brain chemistry. 

Sorry, that got a bit ranty, but I've had to be my own medical advocate for decades and know just how important it is to keep track of all this.  I also know how crippling anxiety and depression can be.  I want to see you able to get help, and as soon as possible. I come back to--call a hematologist/the professor and find out exactly what is going on with your blood condition and then make it clear that you need treatment for anxiety and depression.  Treating one need not mean ignoring the other, but you are the one who ultimately has to make sure that happens and you can do it.

Hello gailleatha,

I had a hip replacement 10 weeks ago and between week 7/8 I developed blood clots in the lungs. I have been put on apixaban for 3 months. Your post that says you had a second P.E 45 days later. That has shocked me that they can return so quickly.

I am 61 and normally healthy, I do not take any medication from the doctor. It was the worst decsion ever to have the hip replacement, I would have preferred managing the pain than having P.E and ruining my health.

I could not take these tablets for life, have the doctors not given you any idea as to why you got another so soon. I am planning on taking bromelain in september when I am finished with the apixaban, it may stop the platelets clotting, certainly worth me trying.